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Browsing by Author "Halbedel, Sven"
Now showing items 1-20 of 31
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2019-01-16ZeitschriftenartikelA Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis Halbedel, Sven; Prager, Rita; Kleta, Sylvia; Trost, Eva; Nishanth, Gopala; Alles, Georg; Hölzel, Christina; Schlesiger, Friederike; Pietzka, Ariane; Schlüter, Dirk; Flieger, Antje; Banerji, SangeetaAn outbreak with a remarkable Listeria monocytogenes clone causing 163 cases of non-invasive listeriosis occurred in Germany in 2015. Core genome multi locus sequence typing grouped non-invasive outbreak isolates and ...
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2024-08-19ZeitschriftenartikelA multicenter study on accuracy and reproducibility of nanopore sequencing-based genotyping of bacterial pathogens Dabernig-Heinz, Johanna; Lohde, Mara; Hölzer, Martin; Cabal, Adriana; Conzemius, Rick; Brandt, Christian; Kohl, Matthias; Halbedel, Sven; Hyden, Patrick; Fischer, Martin A.; Pietzka, Ariane; Daza, Beatriz; Idelevich, Evgeny A.; Stöger, Anna; Becker, Karsten; Fuchs, Stephan; Ruppitsch, Werner; Steinmetz, Ivo; Kohler, Christian; Wagner, Gabriel E.Nanopore sequencing has shown the potential to democratize genomic pathogen surveillance due to its ease of use and low entry cost. However, recent genotyping studies showed discrepant results compared to gold-standard ...
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2022-06-10ZeitschriftenartikelAdaptation of Listeria monocytogenes to perturbation of c-di-AMP metabolism underpins its role in osmoadaptation and identifies a fosfomycin uptake system Wang, Mengyi; Wamp, Sabrina; Gibhardt, Johannes; Holland, Gudrun; Schwedt, Inge; Schmidtke, Kai-Uwe; Scheibner, Katrin; Halbedel, Sven; Commichau, Fabian M.The human pathogen Listeria monocytogenes synthesizes and degrades c-di-AMP using the diadenylate cyclase CdaA and the phosphodiesterases PdeA and PgpH respectively. c-di-AMP is essential because it prevents the uncontrolled ...
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2019-08-06ZeitschriftenartikelCell Shape and Antibiotic Resistance Are Maintained by the Activity of Multiple FtsW and RodA Enzymes in Listeria monocytogenes Rismondo, Jeanine; Halbedel, Sven; Gründling, AngelikaRod-shaped bacteria have two modes of peptidoglycan synthesis: lateral synthesis and synthesis at the cell division site. These two processes are controlled by two macromolecular protein complexes, the elongasome and ...
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2021-02-04ZeitschriftenartikelClosed Genome Sequences of Clinical Listeria monocytogenes PCR Serogroup IVb Isolates Associated with Two Recent Large Listeriosis Outbreaks in Germany Halbedel, Sven; Fischer, Martin A.; Thürmer, Andrea; Flieger, AntjeHere, we report the closed genome sequences of two representative Listeria monocytogenes strains belonging to PCR serogroup IVb, which are related to two large outbreaks of human listeriosis that affected Germany in 2015 ...
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2021-05-06ZeitschriftenartikelComplete Genome Sequences of Three Clinical Listeria monocytogenes Sequence Type 8 Strains from Recent German Listeriosis Outbreaks Fischer, Martin A.; Thürmer, Andrea; Flieger, Antje; Halbedel, SvenWe report here the closed genome sequences of three clinical Listeria monocytogenes strains of multilocus sequence typing (MLST) sequence type 8 (ST8). These strains are representatives of three separate listeriosis outbreak ...
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2023-02-02ZeitschriftenartikelCOVID-19-Pandemie führte zu starkem Rückgang von darmpathogenen Erregern Fruth, Angelika; Simon, Sandra; Halbedel, Sven; Banerji, Sangeeta; Flieger, AntjeIm Zuge der im März 2020 zur Bewältigung der COVID-19-Pandemie ergriffenen Infektionsschutzmaßnahmen wurde nicht nur ein abrupter Rückgang von Atemwegserkrankungen beobachtet, sondern im Verlauf des Jahres auch ein in ...
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2024-09-08ZeitschriftenartikelCytosolic Factors Controlling PASTA Kinase-Dependent ReoM Phosphorylation Rothe, Patricia; Wamp, Sabrina; Rosemeyer, Lisa; Rismondo, Jeanine; Doellinger, Joerg; Gründling, Angelika; Halbedel, SvenBacteria adapt the biosynthesis of their envelopes to specific growth conditions and prevailing stress factors. Peptidoglycan (PG) is the major component of the cell wall in Gram-positive bacteria, where PASTA kinases play ...
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2014-12-19ZeitschriftenartikelDiscrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes Rismondo, Jeanine; Möller, Lars; Aldridge, Christine; Gray, Joe; Vollmer, Waldemar; Halbedel, SvenUpon ingestion of contaminated food, Listeria monocytogenes can cause serious infections in humans that are normally treated with β-lactam antibiotics. These target Listeria's five high molecular weight penicillin-binding ...
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2023-01-13ZeitschriftenartikelDual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion and Bacterial DNA Schäfer, Ann-Britt; Steenhuis, Maurice; Jim, Kin Ki; Neef, Jolanda; O'Keefe, Sarah; Whitehead, Roger C.; Swanton, Eileithyia; Wang, Biwen; Halbedel, Sven; High, Stephen; van Dijl, Jan Maarten; Luirink, Joen; Wenzel, MichaelaEeyarestatin 24 (ES24) is a promising new antibiotic with broad-spectrum activity. It shares structural similarity with nitrofurantoin (NFT), yet appears to have a distinct and novel mechanism: ES24 was found to inhibit ...
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2024-10-07ZeitschriftenartikelHigh density genomic surveillance and risk profiling of clinical Listeria monocytogenes subtypes in Germany Halbedel, Sven; Wamp, Sabrina; Lachmann, Raskit; Holzer, Alexandra; Pietzka, Ariane; Ruppitsch, Werner; Wilking, Hendrik; Flieger, AntjeBackground: Foodborne infections such as listeriosis caused by the bacterium Listeria monocytogenes represent a significant public health concern, particularly when outbreaks affect many individuals over prolonged time. ...
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2020-10-14ZeitschriftenartikelHomöostase der Zellwand in Bakterien Halbedel, Sven
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2022-12-08ZeitschriftenartikelImbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes Schulz, Lisa Maria; Rothe, Patricia; Halbedel, Sven; Gründling, Angelika; Jeanine, RismondoThe bacterial cell wall is composed of a thick layer of peptidoglycan and cell wall polymers, which are either embedded in the membrane or linked to the peptidoglycan backbone and referred to as lipoteichoic acid (LTA) and ...
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2022-05-23ZeitschriftenartikelInvasive listeriosis outbreaks and salmon products: a genomic, epidemiological study Lachmann, Raskit; Halbedel, Sven; Lüth, Stefanie; Holzer, Alexandra; Adler, Marlen; Pietzka, Ariane; Al Dahouk, Sascha; Stark, Klaus; Flieger, Antje; Kleta, Sylvia; Wilking, HendrikInvasive listeriosis, caused by Listeria (L.) monocytogenes, is a severe foodborne infection, especially for immunocompromised individuals. The aim of our investigation was the identification and analysis of listeriosis ...
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2023-04-10ZeitschriftenartikelLarge Multicountry Outbreak of Invasive Listeriosis by a Listeria monocytogenes ST394 Clone Linked to Smoked Rainbow Trout, 2020 to 2021 Halbedel, Sven; Sperle, Ida; Lachmann, Raskit; Kleta, Sylvia; Fischer, Martin A.; Wamp, Sabrina; Holzer, Alexandra; Lüth, Stefanie; Murr, Larissa; Freitag, Christin; Espenhain, Laura; Stephan, Roger; Pietzka, Ariane; Schjørring, Susanne; Bloemberg, Guido; Wenning, Mareike; Al Dahouk, Sascha; Wilking, Hendrik; Flieger, AntjeWhole-genome sequencing (WGS) has revolutionized surveillance of infectious diseases. Disease outbreaks can now be detected with high precision, and correct attribution of infection sources has been improved. Listeriosis, ...
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2022-09-16ZeitschriftenartikelListeria monocytogenes genes supporting growth under standard laboratory cultivation conditions and during macrophage infection Fischer, Martin A.; Engelgeh, Tim; Rothe, Patricia; Fuchs, Stephan; Thürmer, Andrea; Halbedel, SvenThe Gram-positive bacterium Listeria monocytogenes occurs widespread in the environment and infects humans when ingested along with contaminated food. Such infections are particularly dangerous for risk group patients, for ...
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2019-10-09ZeitschriftenartikelListeriose-Ausbruch mit Listeria monocytogenes Sequenz-Cluster-Typ 2521 (Sigma1)in Deutschland Wilking, Hendrik; Lachmann, Raskit; Holzer, Alexandra; Boone, Idesbald; Halbedel, Sven; Flieger, Antje; Stark, KlausMittels Genomsequenzierung wurde im Jahr 2018 ein Listeriose-Cluster mit dem Listerien-Sequenz-Cluster-Typ 2521 im Konsiliarlabor für Listerien im RKI identifiziert. Es besteht nach IfSG eine Labormeldepflicht für L. ...
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2023-03-23ZeitschriftenartikelListeriose-Ausbrüche in Deutschland – Hinweise auf geräucherte oder gebeizte Lachsprodukte als Ursache von Infektionen, Fortschreibung des Berichts aus 2021 Adler, Marlen; Al Dahouk, Sascha; Flieger, Antje; Halbedel, Sven; Holzer, Alexandra; Kleta, Sylvia; Lachmann, Raskit; Lüth, Stefanie; Nöckler, Karsten; Stark, Klaus; Wilking, HendrikListeriose, verursacht durch das Bakterium Listeria (L.) monocytogenes, tritt in verschiedenen Formen auf und wird vor allem durch Konsum kontaminierter Lebensmittel übertragen. Die Krankheit ist mit teilweise schweren ...
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2023-11-29ZeitschriftenartikelListiWiki: A database for the foodborne pathogen Listeria monocytogenes Elfmann, Christoph; Zhu, Bingyao; Stülke, Jörg; Halbedel, SvenListeria monocytogenes is a Gram positive foodborne pathogen that regularly causes outbreaks of systemic infectious diseases. The bacterium maintains a facultative intracellular lifestyle; it thrives under a variety of ...
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2017-10-01ZeitschriftenartikelMolecular Tracing to Find Source of Protracted Invasive Listeriosis Outbreak, Southern Germany, 2012–2016 Kleta, Sylvia; Hammerl, Jens Andre; Dieckmann, Ralf; Malorny, Burkhard; Borowiak, Maria; Halbedel, Sven; Prager, Rita; Trost, Eva; Flieger, Antje; Wilking, Hendrik; Vygen-Bonnet, Sabine; Busch, Ulrich; Messelhäußer, Ute; Horlacher, Sabine; Schönberger, Katharina; Lohr, Dorothee; Aichinger, Elisabeth; Luber, Petra; Hensel, Andreas; Dahouk, Sascha AlWe investigated 543 Listeria monocytogenes isolates from food having a temporal and spatial distribution compatible with that of the invasive listeriosis outbreak occurring 2012–2016 in southern Germany. Using forensic ...