2022-06-28Zeitschriftenartikel
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
Sevdali, Eirini; Block, Violeta; Lataretu, Marie; Li, Huiying; Smulski, Christian R.; Briem, Jana-Susann; Heitz, Yannic; Fischer, Beate; Ramirez, Neftali-Jose; Grimbacher, Bodo; Jäck, Hans-Martin; Voll, Reinhard E.; Hölzer, Martin; Schneider, Pascal; Eibel, Hermann
Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory ...
