Browsing by Author "Mache, Christin"

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2021-11-25Zeitschriftenartikel

Analysis of BNT162b2- and CVnCoV-elicited sera and of convalescent sera toward SARS-CoV-2 viruses

Hein, Sascha; Herrlein, Marie-Luise; Mhedhbi, Ines; Bender, Daniela; Haberger, Vanessa; Benz, Nuka; Eisert, Jonathan; Stingl, Julia; Dreher, Michael; Oberle, Doris; Schulze, Jessica; Mache, Christin; Budt, Matthias; Hildt, Christoph; Wolff, Thorsten; Hildt, Eberhard

Background The mRNA vaccine BNT162b2 (Comirnaty, BioNTech/Pfizer) and the vaccine candidate CVnCoV (Curevac) each encode a stabilized spike protein of SARS-CoV2 as antigen but differ with respect to the nature of the ...
2022-10-27Zeitschriftenartikel

SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell model

Mache, Christin; Schulze, Jessica; Holland, Gudrun; Bourqain, Daniel; Gensch, Jean-Marc; Oh, Djin-Ye; Nitsche, Andreas; Dürrwald, Ralf; Laue, Michael; Wolff, Thorsten

SARS-CoV-2 and its emerging variants of concern remain a major threat for global health. Here we introduce an infection model based upon polarized human Alveolar Epithelial Lentivirus immortalized (hAELVi) cells grown at ...
16-11-20Zeitschriftenartikel

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

Niemeyer, Daniela; Stenzel, Saskia; Veith, Talitha; Schroeder, Simon; Friedmann, Kirstin; Weege, Friederike; Trimpert, Jakob; Heinze, Julian; Richter, Anja; Jansen, Jenny; Emanuel, Jackson; Kazmierski, Julia; Pott, Fabian; Jeworowski, Lara M.; Olmer, Ruth; Jaboreck, Mark-Christian; Tenner, Beate; Papies, Jan; Walper, Felix; Schmidt, Marie L.; Heinemann, Nicolas; Möncke-Buchner, Elisabeth; Baumgardt, Morris; Hoffmann, Karen; Widera, Marek; Thao, Tran Thi Nhu; Balázs, Anita; Schulze, Jessica; Mache, Christin; Jones, Terry Carleton; Morkel, Markus; Ciesek, Sandra; Hanitsch, Leif G.; Mall, Markus A.; Hocke, Andreas C.; Thiel, Volker; Osterrieder, Klaus; Wolff, Thorsten; Martin, Ulrich; Corman, Victor M.; Müller, Marcel A.; Goffinet, Christine; Drosten, Christian

Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. ...