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Browsing by Author "Halbedel, Sven"
Now showing items 21-31 of 31
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2022-03-16ZeitschriftenartikelMurA escape mutations uncouple peptidoglycan biosynthesis from PrkA signaling Wamp, Sabrina; Rothe, Patricia; Stern, Daniel; Holland, Gudrun; Döhling, Janina; Halbedel, SvenGram-positive bacteria are protected by a thick mesh of peptidoglycan (PG) completely engulfing their cells. This PG network is the main component of the bacterial cell wall, it provides rigidity and acts as foundation for ...
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2021-08-09ZeitschriftenartikelOngoing High Incidence and Case-Fatality Rates for Invasive Listeriosis, Germany, 2010–2019 Wilking, Hendrik; Lachmann, Raskit; Holzer, Alexander; Halbedel, Sven; Flieger, Antje; Stark, KlausWe used 10 years of surveillance data to describe lis- teriosis frequency in Germany. Altogether, 5,576 cases were reported, 91% not pregnancy associated; case counts increased over time. Case-fatality rate was 13% in ...
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2015-12-17ZeitschriftenartikelOngoing outbreak of invasive listeriosis, Germany, 2012 to 2015 Ruppitsch, W.; Prager, Rita; Halbedel, Sven; Hyden, P.; Pietzka, A.; Huhulescu, S.; Lohr, D.; Schönberger, K.; Aichinger, Elisabeth; Hauri, Anja M.; Stark, Klaus; Vygen, Sabine; Tietze, Erhard; Allerberger, Franz; Wilking, HendrikListeriosis patient isolates in Germany have shown a new identical pulsed-field gel electrophoresis (PFGE) pattern since 2012 (n = 66). Almost all isolates (Listeria monocytogenes serotype 1/2a) belonged to cases living ...
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2019-07-11ZeitschriftenartikelPadR-type repressors controlling production of a non-canonical FtsW/RodA homologue and other trans-membrane proteins Hauf, Samuel; Möller, Lars; Fuchs, Stephan; Halbedel, SvenThe Gram-positive bacterium Listeria monocytogenes occurs ubiquitously in the environment and infects humans upon ingestion. It encodes four PadR-like repressors, out of which LftR has been characterized previously and was ...
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2020-05-29ZeitschriftenartikelPrkA controls peptidoglycan biosynthesisthrough the essential phosphorylation ofReoM Wamp, Sabrina; Rutter, Zoe J; Rismondo, Jeanine; Jennings, Claire E; Möller, Lars; Lewis, Richard J; Halbedel, SvenPeptidoglycan (PG) is the main component of bacterial cell walls and the target formany antibiotics. PG biosynthesis is tightly coordinated with cell wall growth and turnover, andmany of these control activities depend ...
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2012-12-21ZeitschriftenartikelProtein-Protein Interaction Domains of Bacillus subtilis DivIVA Baarle, Suey van; Celik, Ilkay Nazli; Kaval, Karan Gautam; Bramkamp, Marc; Hamoen, Leendert W.; Halbedel, SvenDivIVA proteins are curvature-sensitive membrane binding proteins that recruit other proteins to the poles and the division septum. They consist of a conserved N-terminal lipid binding domain fused to a less conserved ...
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2014-02-14ZeitschriftenartikelSecA is required for membrane targeting of the cell division protein DivIVA in vivo Halbedel, Sven; Kawai, Maki; Breitling, Reinhard; Hamoen, Leendert W.The conserved protein DivIVA is involved in different morphogenetic processes in Gram-positive bacteria. In Bacillus subtilis, the protein localizes to the cell division site and cell poles, and functions as a scaffold for ...
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2023-10-07ZeitschriftenartikelTartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon Engelgeh, Tim; Hermann, Jennifer; Jansen, Rolf; Müller, Rolf; Halbedel, SvenListeria monocytogenes is a foodborne bacterium that naturally occurs in the soil. Originating from there, it contaminates crops and infects farm animals and their consumption by humans may lead to listeriosis, a systemic ...
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2019-01-16ZeitschriftenartikelThe cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes Cleverley, Robert M.; Rutter, Zoe J.; Rismondo, Jeanine; Corona, Federico; Tsui, Ho-Ching Tiffany; Alatawi, Fuad A.; Daniel, Richard A.; Halbedel, Sven; Massidda, Orietta; Winkler, Malcolm E.; Lewis, Richard J.Bacterial growth and cell division requires precise spatiotemporal regulation of the synthesis and remodelling of the peptidoglycan layer that surrounds the cytoplasmic membrane. GpsB is a cytosolic protein that affects ...
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2015-07-28ZeitschriftenartikelThe PadR-like transcriptional regulator LftR ensures efficient invasion of Listeria monocytogenes into human host cells Kaval, Karan G.; Hahn, Birgitt; Tusamda, Nayana; Albrecht, Dirk; Halbedel, SvenInvasion of the bacterial pathogen Listeria monocytogenes into human host cells requires specialized surface molecules for attachment and induction of phagocytosis. However, efficient invasion is also dependent on factors ...
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2013-05-23ZeitschriftenartikelThe resuscitation promotion concept extends to firmicutes Commichau, Fabian M.; Halbedel, Sven