Auflistung nach Titel
Anzeige der Publikationen 6600-6619 von 11403
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2016-06-16ZeitschriftenartikelOnly the complex N559-glycan in SV2C mediates high affinity binding to botulinum neurotoxin serotype A1 The extraordinary potency of botulinum neurotoxins (BoNTs) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid paralysis and successive respiratory failure. Complex ...
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2014-07-28ZeitschriftenartikelOntogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor ...
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2021-02-11Berichte und sonstige TexteOperationalisierung der übermittelten Daten nach KHG §21 Absatz 1a Satz 8 Operationalisierung der Datenausleitung nach §21 KHG
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2021-05-31ZeitschriftenartikelOperationalising One Health in Nigeria: Reflections From a High-Level Expert Panel Discussion Commemorating the 2020 World Antibiotics Awareness Week Antimicrobial resistance (AMR) poses an important One Health challenge for all countries of the world. As human, animal and environmental health are closely linked, it is essential that interventions targeted at reducing ...
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2011-02-25ZeitschriftenartikelOperationalizing multimorbidity and autonomy for health services research in aging populations - the OMAHA study Background: As part of a Berlin-based research consortium on health in old age, the OMAHA (Operationalizing Multimorbidity and Autonomy for Health Services Research in Aging Populations) study aims to develop a conceptual ...
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2018-10-02ZeitschriftenartikelOpportunistic HPV vaccination at age 16–23 and cervical screening attendance in Sweden: a national register-based cohort study Objectives To investigate whether cervical screening attendance differs between human papillomavirus (HPV)-vaccinated and unvaccinated women and to investigate potential underlying socioeconomic factors. Design Prospective ...
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2018-08-09MasterarbeitOptimierung von PCR-Methoden zur sensitiven Quantifizierung und Charakterisierung des proviralen Reservoirs in HIV-1 infizierten Patienten Die hochaktive antiretrovirale Therapie (HAART) ermöglicht die Suppression der Plasma-virämie eines HIV-1 Patienten bis unter die Nachweisgrenze. Eine vollständige Eradikation des Virus ist jedoch mit antiretroviralen ...
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2011-09-24ZeitschriftenartikelOptimisation of expression and purification of the feline and primate foamy virus transmembrane envelope proteins using a 96 deep well screen The production of recombinant transmembrane proteins is due to their biochemical properties often troublesome and time consuming. Here the prokaryotic expression and purification of the transmembrane envelope proteins of ...
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2018-04-19ZeitschriftenartikelOptimisation of quantitative miRNA panels to consolidate the diagnostic surveillance of HBV-related hepatocellular carcinoma Background: Circulating microRNAs (miRNA) are biomarkers for several neoplastic diseases, including hepatocellular carcinoma (HCC). We performed a literature search, followed by experimental screening and validation in ...
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2019-10-11ZeitschriftenartikelOptimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments The detection of catalytically active botulinum neurotoxins (BoNTs) can be achieved by monitoring the enzymatic cleavage of soluble NSF (N-ethylmaleimide-sensitive-factor) attachment protein receptor (SNARE) proteins by ...
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2018-12-12ZeitschriftenartikelOral health behaviour of children and adolescents in Germany. Results of the cross-sectional KiGGS Wave 2 study and trends Oral health behaviour plays a key role in the prevention of caries and periodontitis. This article describes the prevalence, determinants and trends of tooth brushing frequency and utilization of dental check-ups. The ...
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2009-12-18ZeitschriftenartikelOrbus hercynius gen. nov., sp. nov., isolated from faeces of wild boar, is most related to Enterobacteriales and Pasteurellales A novel gammaproteobacterium, strain CN3T, was isolated from faeces of wild boar. It is facultative anaerobic and appears coccoid or rod shaped. The determined partial 16S rRNA gene sequence of strain CN3T suggests a distant ...
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2016-09-13ZeitschriftenartikelOrganization and ELISA-Based Results of the First Proficiency Testing to Evaluate the Ability of European Union Laboratories to Detect Staphylococcal Enterotoxin Type B (SEB) in Buffer and Milk The aim of this work was to organize the first proficiency test (PT) dedicated to staphylococcal enterotoxin B (SEB) detection in milk and buffer solutions. This paper describes the organization of the PT trial according ...
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2014-04-01ZeitschriftenartikelOrigin Detection During Food-borne Disease Outbreaks – A Case Study of the 2011 EHEC/HUS Outbreak in Germany The key challenge during food-borne disease outbreaks, e.g. the 2011 EHEC/HUS outbreak in Germany, is the design of efficient mitigation strategies based on a timely identification of the outbreak’s spatial origin. Standard ...
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2012-04-01ZeitschriftenartikelOrigin of Human T-Lymphotropic Virus Type 1 in Rural Côte d’Ivoire Simian T-lymphotropic virus type 1 (STLV-1) strains occasionally infect humans. However, the frequency of such infections is unknown. We show that direct transmission of STLV-1 from nonhuman primates to humans may be ...
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2011-07-27ZeitschriftenartikelOrigin of XMRV and its Demise as a Human Pathogen Associated with Chronic Fatigue Syndrome Retroviruses are well known pathogens of mammals, birds and fish. Their potential to induce cancer in chickens was already described almost 100 years ago and murine retroviruses have been a subject of study for 50 years. ...
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2017-11-20ZeitschriftenartikelOrigin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8 USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite its high clinical relevance, the evolutionary ...
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2020-02-25ZeitschriftenartikelOrthohepevirus C: An Expanding Species of Emerging Hepatitis E Virus Variants Hepatitis E virus (HEV) is an emerging zoonotic pathogen that has received an increasing amount of attention from virologists, clinicians, veterinarians, and epidemiologists over the past decade. The host range and animal ...
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2010-06-07Berichte und sonstige TexteOrthopockenviren: Infektionen des Menschen Stellungnahme des AK Blut
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2009-11-19ZeitschriftenartikelOseltamivir-resistant influenza A(H1N1) viruses detected in Europe during season 2007-8 had epidemiologic and clinical characteristics similar to co-circulating susceptible A(H1N1) viruses During the 2007-08 influenza season, high levels of oseltamivir resistance were detected among influenza A(H1N1) viruses in a number of European countries. We used surveillance data to describe influenza A(H1N1) cases for ...