Auflistung nach Titel
Anzeige der Publikationen 6989-7008 von 11403
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2020-04-19ZeitschriftenartikelPromoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts believed to be the natural host cell. However, this virus is the major ...
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2021-08-20ZeitschriftenartikelPropagation of CJD Prions in Primary Murine Glia Cells Expressing Human PrPc There are various existing cell models for the propagation of animal prions. However, in vitro propagation of human prions has been a long-standing challenge. This study presents the establishment of a long-term primary ...
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2006-09-01ZeitschriftenartikelPropagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters As is known from various animal models, the spread of agents causing transmissible spongiform encephalopathies (TSE) after peripheral infection affects peripheral nerves before reaching the central nervous system (CNS) ...
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2006-12-21ZeitschriftenartikelPropagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters As is known from various animal models, the spread of agents causing transmissible spongiform encephalopathies (TSE) after peripheral infection affects peripheral nerves before reaching the central nervous system (CNS) and ...
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2011-07-20ZeitschriftenartikelProspective genomic characterization of the German enterohemorrhagic escherichia coli O104:H4 outbreak by rapid next generation sequencing technology. An ongoing outbreak of exceptionally virulent Shiga toxin (Stx)-producing Escherichia coli O104:H4 centered in Germany, has caused over 830 cases of hemolytic uremic syndrome (HUS) and 46 deaths since May 2011. Serotype ...
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2012-05-31ZeitschriftenartikelProspective hospital-based case–control study to assess the effectiveness of pandemic influenza A(H1N1)pdm09 vaccination and risk factors for hospitalization in 2009–2010 using matched hospital and test-negative controls Background: We performed a case–control study to estimate vaccine effectiveness (VE) for prevention of hospitalization due to pandemic influenza A(H1N1)pdm09 (pH1N1) and to identify risk factors for pH1N1 and acute ...
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2017-02-08ZeitschriftenartikelProspective multicenter German study on pulmonary colonization with Scedosporium /Lomentospora species in cystic fibrosis: Epidemiology and new association factors Background: An increasing rate of respiratory colonization and infection in cystic fibrosis (CF) is caused by fungi of the Scedosporium apiospermum species complex or Lomentospora prolificans (Sac-Lp). These fungi rank ...
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2016-05-24Berichte und sonstige TexteProtecting Health – Assessing Risks Who we are? What we look back on? What we do and will do?
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2012-12-11ZeitschriftenartikelProtecting society: Biological security and dual-use dilemma in the life sciences-status quo and options for the future Life science research is a main pillar of health care; major discoveries have considerably improved life expectancy and quality of life. However, research, technologies and materials that can be used for good can also be ...
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2017-07-12ZeitschriftenartikelProtection of farm goats by combinations of recombinant peptides and formalin inactivated spores from a lethal Bacillus anthracis challenge under field conditions Background: Bacillus (B.) anthracis, the causal agent of anthrax, is effectively controlled by the Sterne live spore vaccine (34F2) in animals. However, live spore vaccines are not suitable for simultaneous vaccination ...
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2009-10-18ZeitschriftenartikelProtective measures and H5N1-seroprevalence among personnel tasked with bird collection during an outbreak of avian influenza A/H5N1 in wild birds, Ruegen, Germany, 2006 Background: In Germany, the first outbreak of highly pathogenic avian influenza A/H5N1 occurred among wild birds on the island of Ruegen between February and April 2006. The aim of this study was to investigate the ...
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2013-02-28ZeitschriftenartikelProtein function prediction using domain families Here we assessed the use of domain families for predicting the functions of whole proteins. These 'functional families' (FunFams) were derived using a protocol that combines sequence clustering with supervised cluster ...
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2012-12-21ZeitschriftenartikelProtein-Protein Interaction Domains of Bacillus subtilis DivIVA DivIVA proteins are curvature-sensitive membrane binding proteins that recruit other proteins to the poles and the division septum. They consist of a conserved N-terminal lipid binding domain fused to a less conserved ...
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2011-08-01ZeitschriftenartikelProteome analysis of vaccinia virus IHD-W-infected HEK 293 cells with 2-dimensional gel electrophoresis and MALDI-PSD-TOF MS of on solid phase support N-terminally sulfonated peptides Background: Despite the successful eradication of smallpox by the WHO-led vaccination programme, pox virus infections remain a considerable health threat. The possible use of smallpox as a bioterrorism agent as well as ...
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2015-11-02ZeitschriftenartikelProteomic analysis of protein carbonylation: a useful tool to unravel nanoparticle toxicity mechanisms Background: Oxidative stress, a commonly used paradigm to explain nanoparticle (NP)-induced toxicity, results from an imbalance between reactive oxygen species (ROS) generation and detoxification. As one consequence, ...
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2014-12-15ZeitschriftenartikelProtocol for Metagenomic Virus Detection in Clinical Specimens Sixty percent of emerging viruses have a zoonotic origin, making transmission from animals a major threat to public health. Prompt identification and analysis of these pathogens are indispensable to taking action toward ...
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2007-09-13ZeitschriftenartikelProtracted outbreak of S. Enteritidis PT 21c in a large Hamburg nursing home Background: During August 2006, a protracted outbreak of Salmonella (S.) Enteritidis infections in a large Hamburg nursing home was investigated. Methods: A site visit of the home was conducted and food suppliers' premises ...
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2013-06-11ZeitschriftenartikelProvenance and Geographic Spread of St. Louis Encephalitis Virus St. Louis encephalitis virus (SLEV) is the prototypic mosquito-borne flavivirus in the Americas. Birds are its primary vertebrate hosts, but amplification in certain mammals has also been suggested. The place and time of ...
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2020-06-04ZeitschriftenartikelProviding actionable evidence in Public Health – The 2018 international workshop on evidence-based public health at the Robert Koch Institute, Berlin
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2022StudienarbeitPrüfung der Validität komplexer Analysen mit synthetisierten Krebsregisterdaten Ziel des Forschungsvorhabens ist es, publizierte Analysen der Krebsregisterdaten zum Glioblastom* mit synthetisierten Daten zu replizieren. Zweck des Forschungsvorhabens ist eine mögliche Nutzung von synthetisierten Daten ...