TY - GEN T1 - The role of XCR1 and its ligand XCL1 in antigen cross-presentation by murine and human dendritic cells AU - Kroczek, Richard AU - Henn, Volker AB - Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of dendritic cell (DC) known to be involved in antigen cross-presentation. This review aims to summarize the known biology of the XCR1 receptor and its chemokine ligand XCL1, both in the mouse and the human. Further, any involvement of this receptor–ligand pair in antigen uptake, cross-presentation, and induction of innate and adaptive cytotoxic immunity is explored. The concept of antigen delivery to DC via the XCR1 receptor is discussed as a vaccination strategy for selective induction of cytotoxic immunity against certain pathogens or tumors. KW - vaccination KW - dendritic cells KW - XCR1 KW - XCL1 KW - antigen cross-presentation KW - antigen targeting KW - 610 Medizin PY - 2012 LA - eng PB - Robert Koch-Institut VL - 3 IS - 14 DO - 10.3389/fimmu.2012.00014 ER -