TY - GEN T1 - Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran AU - Chinikar, Sadegh AU - Shah-Hosseini, Nariman AU - Bouzari, Saeid AU - Shokrgozar, Mohammad Ali AU - Mostafavi, Ehsan AU - Jalali, Tahmineh AU - Khakifirouz, Sahar AU - Groschup, Martin H. AU - Niedrig, Matthias AB - Background: Crimean-Congo Hemorrhagic Fever Virus (CCHFV) belongs to genus Nairovirus and family Bunyaviridae. The main aim of this study was to investigate the extent of recombination in S-segment genome of CCHFV in Iran. Methods: Samples were isolated from Iranian patients and those available in GenBank, and analyzed by phyloge­netic and bootscan methods. Results: Through comparison of the phylogenetic trees based on full length sequences and partial fragments in the S-segment genome of CCHFV, genetic switch was evident, due to recombination event. Moreover, evidence of multi­ple recombination events was detected in query isolates when bootscan analysis was used by SimPlot software. Conclusion: Switch of different genomic regions between different strains by recombination could contribute to CCHFV diversification and evolution. The occurrence of recombination in CCHFV has a critical impact on epidemi­ological investigations and vaccine design. KW - Phylogenetic KW - Recombination KW - Diversity KW - Crimean Congo Hemorrhagic Fever KW - Iran KW - 610 Medizin PY - 2016 LA - eng PB - Robert Koch-Institut, Biologische Sicherheit VL - 10 IS - 1 DO - http://dx.doi.org/10.25646/2318 ER -