TY - GEN T1 - Adenovirus in Rural Côte D`Ivoire: High Diversity and Cross-Species Detection AU - Pauly, Maude AU - Akoua-Koffi, Chantal AU - Buchwald, Nanina AU - Schubert, Grit AU - Weiss, Sabrina AU - Couacy-Hymann, Emmanuel AU - Anoh, Augustin Etile AU - Mossoun, Arsène AU - Calvignac-Spencer, Sébastien AU - Leendertz, Siv Aina AU - Leendertz, Fabian H. AU - Ehlers, Bernhard AB - The Taï region in Western Côte d`Ivoire is characterized by extensive overlap of human and animal habitats. This could influence patterns of adenovirus transmission between humans and domestic animals. Fecal samples from humans and various domestic animals were tested for the presence of adenoviruses by PCR. Phylogenetic and species delineation analyses were performed to further characterize the adenoviruses circulating in the region and to identify potential cross-species transmission events. Among domestic animals, adenovirus shedding was frequent (21.6% of domestic mammals and 41.5% of chickens) and the detected strains were highly diverse, several of them representing novel types. Although no evidence for zoonotic transmission of animal adenovirus was obtained, the present study provides concordant evidence in favor of common cross-species transmission of adenoviruses between different animal species and first indications for adenovirus transmission from humans to animals. These findings underline the thus far underestimated importance of reverse zoonotic transmission of viruses and of the role of domestic animals as pathogen reservoirs, “bridge species,” or intermediate hosts. KW - Phylogeny KW - Adenoviridae KW - Sub-Saharan Africa KW - Transmission Classification KW - 610 Medizin PY - 2015 LA - eng PB - Robert Koch-Institut, Infektionskrankheiten / Erreger VL - 12 IS - 3 DO - 10.1007/s10393-015-1032-5 ER -