TY - JOUR T1 - Orthohepevirus C: An Expanding Species of Emerging Hepatitis E Virus Variants AU - Wang, Bo AU - Harms, Dominik AU - Yang, Xing-Lou AU - Bock, Claus-Thomas AB - Hepatitis E virus (HEV) is an emerging zoonotic pathogen that has received an increasing amount of attention from virologists, clinicians, veterinarians, and epidemiologists over the past decade. The host range and animal reservoirs of HEV are rapidly expanding and a plethora of emerging HEV variants have been recently identified, some of which have the potential for interspecies infection. In this review, the detection of genetically diverse HEV variants, classified into and presumably associated with the species Orthohepevirus C, currently comprising HEV genotypes C1 and C2, by either serological or molecular approach is summarized. The distribution, genomic variability, and evolution of Orthohepevirus C are analyzed. Moreover, the potential risk of cross-species infection and zoonotic transmission of Orthohepevirus C are discussed. KW - Orthohepevirus C KW - hepatitis E virus KW - genetic variability KW - molecular evolution KW - host KW - zoonosis KW - 610 Medizin und Gesundheit PY - 2020 LA - eng PB - Robert Koch-Institut JO - pathgens VL - 9 IS - 154 SP - 1 EP - 23 DO - 10.3390/pathogens9030154 ER -