TY - GEN T1 - Time trends of syphilis and HSV-2 co-infection among men who have sex with men in the German HIV-1 seroconverter cohort from 1996–2007 AU - Spielmann, Nadine AU - Münstermann, Dieter AU - Hagedorn, Hans-Jochen AU - Heiden, Matthias an der AU - Houareau, Claudia AU - Gunsenheimer-Bartmeyer, Barbara AU - Kücherer, Claudia AU - Keeren, Katrin AU - Hamouda, Osamah AU - Marcus, Ulrich AB - Objectives: Numbers of newly diagnosed HIV infections among men who have sex with men (MSM) in Germany increased after the year 2000. We sought to explore trends in STI co-infections around the time of HIV seroconversion in patients from the German HIV-1 seroconverter cohort from 1996-2007. Methods: MSM from the cohort were included forsecondary analysis, if seroconversion occurred between 1996 and 2007 and if a blood sample taken within 2 y after HIV infection was available for further testing. Samples were tested for antibodies against Treponema pallidum and HSV-2. A classification system was developed to assign the chronology of syphilis and HIV-1 infection. Results: Data of 1052 MSM were eligible for analysis. Overall seroprevalence of syphilis markers was 26%, increasing from 10% (1996-1999) to 35% (2005). Among HIV seroconverters with positive syphilis antibodies, 32% (n=88) were rated as having had coincident infections with HIV and syphilis. Coincident syphilis infection at HIV diagnosis increased substantially (p KW - Adult KW - Humans KW - Germany/epidemiology KW - Male KW - Incidence KW - Time Factors KW - Prospective Studies KW - HIV Seropositivity/epidemiology KW - Syphilis/epidemiology KW - HIV-1/immunology KW - HIV Seropositivity/complications KW - Homosexuality Male/statistics & numerical data KW - Herpes Genitalis/complications KW - Herpes Genitalis/epidemiology KW - Herpesvirus 2 Human/immunology KW - Poisson Distribution KW - Syphilis/complications KW - 610 Medizin PY - 2010 LA - eng PB - Robert Koch-Institut, Infektionsepidemiologie VL - 86 IS - 5 DO - 10.1136/sti.2009.040857 ER -