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Now showing items 1011-1020 of 11373

2018-01-30Zeitschriftenartikel

Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody

Füzik, Tibor; Formanová, Petra; Růžek, Daniel; Yoshii, Kentaro; Niedrig, Matthias; Plevka, Pavel

Tick-borne encephalitis virus (TBEV) causes 13,000 cases of human meningitis and encephalitis annually. However, the structure of the TBEV virion and its interactions with antibodies are unknown. Here, we present cryo-EM ...

2018-01-14Zeitschriftenartikel

Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection

Sy, Bui Tien; Hoan, Nghiem Xuan; Tong, Hoang Van; Meyer, Christian G.; Toan, Nguyen Linh; Song, Le Huu; Bock, Thomas; Velavan, Thirumalaisamy P.

Aim: To investigate possible effects of IRF5 polymorphisms in the 3’ UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified ...

2018-01-30Zeitschriftenartikel

Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Acinetobacter baumannii among horses entering a veterinary teaching hospital: The contemporary "Trojan Horse"

Walther, Birgit; Klein, Katja-Sophia; Barton, Ann-Kristin; Semmler, Torsten; Huber, Charlotte; Wolf, Silver Anthony; Tedin, Karsten; Merle, Roswitha; Mitrach, Franziska; Guenther, Sebastian; Lübke-Becker, Antina; Gehlen, Heidrun

Pathogens frequently associated with multi-drug resistant (MDR) phenotypes, including extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and Acinetobacter baumannii isolated from horses admitted ...

2018-02-09Zeitschriftenartikel

Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population

Schaufler, Katharina; Nowak, Kathrin; Düx, Ariane; Semmler, Torsten; Villa, Laura; Kourouma, Laye; Bangoura, Karim; Wieler, Lothar H.; Leendertz, Fabian H.; Guenther, Sebastian

High-risk ESBL-producing Enterobacteriaceae (ESBL-E) have been described in wild birds and rodents worldwide. Rats are of special interest not only due to their indicator role for environmental pollution with multi-resistant ...

2017-12-20Zeitschriftenartikel

Salon zur Institutsgeschichte: Das besondere Stück. 28.01.2016 bis 15.12.2016

Heldt, Katharina; Senst, Henriette; Riedel, Jessica

Das Robert Koch-Institut (RKI) feierte im Jahr 2016 den 125. Jahrestag seiner Gründung. Die Bibliothek trug durch eine Reihe von Aktivitäten zur Gestaltung des Jubiläumsjahres bei. Unter anderem wurde in der Bibliothek die ...

2017-11-18Zeitschriftenartikel

Legislation of direct-to-consumer genetic testing in Europe: a fragmented regulatory landscape

Kalokairinou, L.; Howard, H. C.; Slokenberga, S.; Fisher, Eva; Flatscher-Thöni, M.; Hartlev, M.; Hellemondt, R. van; Juškevičius, J.; Kapelenska-Pregowska, J.; Kováč, P.; Lovrečić, L.; Nys, Helene de; Paor, A. de; Phillips, A.; Prudil, L.; Rial-Sebbag, E.; Casabona, C. M. Romeo; Sándor, J.; Schuster, A.; Soini, S.; Søvig, K. H.; Stoffel, D.; Titma, T.; Trokanas, T.; Borry, P.

Despite the increasing availability of direct-to-consumer (DTC) genetic testing, it is currently unclear how such services are regulated in Europe, due to the lack of EU or national legislation specifically addressing this ...

2018-02-27Zeitschriftenartikel

Erfassung inzidenter kardiovaskulärer und metabolischer Erkrankungen in epidemiologischen Kohortenstudien in Deutschland

Herrmann, Wolfram J.; Weikert, Cornelia; Bergmann, Manuela; Boeing, Heiner; Katzke, Verena A.; Kaaks, Rudolf; Tiller, Daniel; Greiser, Karin Halina; Heier, Margit; Meisinger, Christa; Schmidt, Carsten Oliver; Neuhauser, Hannelore; Heidemann, Christin; Jünger, Claus; Wild, Philipp S.; Schramm, Sara Helena; Jöckel, Karl-Heinz; Dörr, Marcus; Pischon, Tobias

Hintergrund: Kardiovaskuläre und metabolische Erkrankungen sind häufige Ursachen für Mortalität und Verlust von Lebensqualität in der deutschen Bevölkerung. Zur Erforschung von Risikofaktoren sind populationsbasierte ...

2018-04-02Zeitschriftenartikel

Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

Denner, Joachim

Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs. Xenotransplantation ...

2018-03-14Zeitschriftenartikel

Construction of a New Phage Integration Vector pFIV-Val for Use in Different Francisella Species

Tlapák, Hana; Köppen, Kristin; Rydzewski, Kerstin; Grunow, Roland; Heuner, Klaus

We recently identified and described a putative prophage on the genomic island FhaGI-1 located within the genome of Francisella hispaniensis AS02-814 (F. tularensis subsp. novicida-like 3523). In this study, we constructed ...

2018-03-15Zeitschriftenartikel

Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis

Baddam, Ramani; Kumar, Narender; Wieler, Lothar H.; Lankapalli, Aditya Kumar; Ahmed, Niyaz; Peacock, Sharon J.; Semmler, Torsten

Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, resistance to which occurs primarily due to mutations in pncA (Rv2043c) that encodes the pyrazinamidase enzyme responsible for conversion of pro-drug ...

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