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2017-09-26Zeitschriftenartikel

Socioeconomic Inequalities in Health and Perceived Unmet Needs for Healthcare among the Elderly in Germany

Hoebel, Jens; Rommel, Alexander; Schröder, Sara Lena; Fuchs, Judith; Nowossadeck, Enno; Lampert, Thomas

Research into health inequalities in the elderly population of Germany is relatively scarce. This study examines socioeconomic inequalities in health and perceived unmet needs for healthcare and explores the dynamics of ...

2018-02-02Zeitschriftenartikel

Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis

Karayel, Özge; Şanal, Erdem; Giese, Sven H.; Kagıalı, Zeynep Cansu Üretmen; Polat, Ayşe Nur; Hu, Chi-Kuo; Renard, Bernhard Y.; Tuncbag, Nurcan; Özlü, Nurhan

The successful completion of cytokinesis requires the coordinated activities of diverse cellular components including membranes, cytoskeletal elements and chromosomes that together form partly redundant pathways, depending ...

2017-11-27Zeitschriftenartikel

Evaluating the Impact of Functional Genetic Variation on HIV-1 Control

McLaren, Paul J.; Pulit, Sara L.; Gurdasani, Deepti; Bartha, Istvan; Shea, Patrick R.; Pomilla, Cristina; Gupta, Namrata; Gkrania-Klotsas, Effrossyni; Young, Elizabeth H.; Bannert, Norbert; Amo, Julia Del; Gill, M. John; Gilmour, Jill; Kellam, Paul; Kelleher, Anthony D.; Sönnerborg, Anders; Zangerle, Robert; Post, Frank A.; Fisher, Martin; Haas, David W.; Walker, Bruce D.; Porter, Kholoud; Goldstein, David B.; Sandhu, Manjinder S.; Fellay, Jacques

Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought ...

2018-02-15Zeitschriftenartikel

High-Throughput Quantification of Bacterial-Cell Interactions Using Virtual Colony Counts

Hoffmann, Stefanie; Walter, Steffi; Blume, Anne-Kathrin; Fuchs, Stephan; Schmidt, Christiane; Scholz, Annemarie; Gerlach, Roman G.

The quantification of bacteria in cell culture infection models is of paramount importance for the characterization of host-pathogen interactions and pathogenicity factors involved. The standard to enumerate bacteria in ...

2016-11-25Zeitschriftenartikel

Characterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin

Schultheis, Katherine; Schäfer, Hubert; Yung, Bryan S.; Oh, Janet; Muthumani, Karuppiah; Humeau, Laurent; Broderick, Kate E.; Smith, Trevor R.F.

The skin is an ideal target tissue for vaccine delivery for a number of reasons. It is highly accessible, and most importantly, enriched in professional antigen presenting cells. Possessing strong similarities to human ...

2017-12-07Zeitschriftenartikel

MPA Portable: A Stand-Alone Software Package for Analyzing Metaproteome Samples on the Go

Muth, Thilo; Kohrs, Fabian; Heyer, Robert; Benndorf, Dirk; Rapp, Erdmann; Reichl, Udo; Martens, Lennart; Renard, Bernhard Y.

Metaproteomics, the mass spectrometry-based analysis of proteins from multispecies samples faces severe challenges concerning data analysis and results interpretation. To overcome these shortcomings, we here introduce ...

2017-11-10Zeitschriftenartikel

Capturing virus evolution by proteomic bioinformatics: Hunting for characteristic mutations in the hepatitis E virus genome

Harms, Dominik; Wang, Bo; Papp, C. Patrick; Bock, Thomas

2017-11-14Zeitschriftenartikel

Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors

Meixenberger, Karolin; Yousef, Kaveh Pouran; Smith, Maureen Rebecca; Somogyi, Sybille; Fiedler, Stefan; Bartmeyer, Barbara; Hamouda, Osamah; Bannert, Norbert; Kleist, Max von; Kücherer, Claudia

Background: Detailed knowledge of the evolutionary potential of polymorphic sites in a viral protein is important for understanding the development of drug resistance in the presence of an inhibitor. We therefore set ...

2017-11-24Zeitschriftenartikel

Disulfide loop cleavage of Legionella pneumophila PlaA boosts lysophospholipase A activity

Lang, Christina; Hiller, Miriam; Flieger, Antje

L. pneumophila, an important facultative intracellular bacterium, infects the human lung and environmental protozoa. At least fifteen phospholipases A (PLA) are encoded in its genome. Three of which, namely PlaA, PlaC, and ...

2017-04-25Zeitschriftenartikel

Influenza viruses – antiviral therapy and resistance

Influenza is a serious and frequently underestimated, but vaccine preventable disease. The adamantane derivates rimantadine and amantadine and the neuraminidase inhibitors zanamivir and oseltamivir are the only antiviral ...

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