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2023-04-02Zeitschriftenartikel

Monitoring the SARS-CoV-2 Pandemic: Prevalence of Antibodies in a Large, Repetitive Cross-Sectional Study of Blood Donors in Germany—Results from the SeBluCo Study 2020–2022

Offergeld, Ruth; Preußel, Karina; Zeiler, Thomas; Aurich, Konstanze; Baumann-Baretti, Barbara I.; Ciesek, Sandra; Corman, Victor M.; Dienst, Viktoria; Drosten, Christian; Görg, Siegfried; Greinacher, Andreas; Grossegesse, Marica; Haller, Sebastian; Heuft, Hans-Gert; Hofmann, Natalie; Horn, Peter A.; Houareau, Claudia; Gülec, Ilay; Jiménez Klingberg, Carlos Luis; Juhl, David; Lindemann, Monika; Martin, Silke; Neuhauser, Hannelore K.; Nitsche, Andreas; Ohme, Julia; Peine, Sven; Sachs, Ulrich J.; Schaade, Lars; Schäfer, Richard; Scheiblauer, Heinrich; Schlaud, Martin; Schmidt, Michael; Umhau, Markus; Vollmer, Tanja; Wagner, Franz F.; Wieler, Lothar H.; Wilking, Hendrik; Ziemann, Malte; Zimmermann, Marlow; an der Heiden, Matthias

SARS-CoV-2 serosurveillance is important to adapt infection control measures and estimate the degree of underreporting. Blood donor samples can be used as a proxy for the healthy adult population. In a repeated cross-sectional ...

2023-02-10Zeitschriftenartikel

Disease severity in hospitalized COVID-19 patients: comparing routine surveillance with cohort data from the LEOSS study in 2020 in Germany

Koppe, Uwe; Schilling, Julia; Stecher, Melanie; Rüthrich, Maria Madeleine; Marquis, Adine; Diercke, Michaela; Haselberger, Martina; Koll, Carolin E. M.; Niebank, Michaela; Ruehe, Bettina; Borgmann, Stefan; Grabenhenrich, Linus; Hellwig, Kerstin; Pilgram, Lisa; Spinner, Christoph D.; Paerisch, Thomas

Introduction Studies investigating risk factors for severe COVID-19 often lack information on the representativeness of the study population. Here, we investigate factors associated with severe COVID-19 and compare the ...

2022-12-21Zeitschriftenartikel

Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia

Saghuag, Christina S.; Gamlem, Astrid L.; Hauge, Kirsti B.; Vahokoski, Juha; Klotz, Christian; Langeland, Nina; Hanevik, Kurt; Aebischer, Toni

The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ...

2023-02-10Zeitschriftenartikel

Self-rated health of university students in Germany–The importance of material, psychosocial, and behavioral factors and the parental socio-economic status

Deindl, Christian; Diehl, Katharina; Spalleck, Jacob; Richter, Matthias; Schüttig, Wiebke; Rattay, Petra; Dragano, Nico; Pischke, Claudia R.

Introduction: Health inequalities start early in life. The time of young adulthood, between late teens and early twenties, is especially interesting in this regard. This time of emerging adulthood, the transition from being ...

2021-07-02Zeitschriftenartikel

The increasing significance of disease severity in a burden of disease framework

Wyper, Grant M. A.; Assuncao, Ricardo; Fletcher, Eilidh; Gourley, Michelle; Grant, Ian; Haagsma, Juanita A.; Hilderink, Henk; Idavain, Jane; Lesnik, Tina; von der Lippe, Elena; Majdan, Marek; Mccartney, Gerry; Santric-Milicevic, Milena; Pallari, Elena; Pires, Sara M.; Plass, Dietrich; Porst, Michael; Santos, João V.; de Haro Moro, Maria Teresa; Stockton, Diane L.; Devleesschauwer, Brecht

Recent estimates have reiterated that non-fatal causes of disease, such as low back pain, headaches and depressive disorders, are amongst the leading causes of disability-adjusted life years (DALYs). For these causes, the ...

2023-02-21Zeitschriftenartikel

Gesundheitliche Chancengleichheit in Krisenzeiten

Saß, Anke-Christine

2023-01-11Zeitschriftenartikel

Comparison of a Genotype 1 and a Genotype 2 Macaque Foamy Virus env Gene Indicates Distinct Infectivity and Cell-Cell Fusion but Similar Tropism and Restriction of Cell Entry by Interferon-Induced Transmembrane Proteins

Fricke, Thomas; Schlagowski, Sarah; Liu, Shanchuan; Yang, Xiaoling; Fiebig, Uwe; Kaul, Artur; Ensser, Armin; Hahn, Alexander S.

Foamy viruses (FVs) are naturally found in many different animals and also in primates with the notable exception of humans, but zoonotic infections are common. In several species, two different envelope (env) gene ...

2023-02-25Rezension

Anakinra for the treatment of COVID-19 patients: a systematic review and meta-analysis

Dahms, Karolina; Mikolajewska, Agata; Ansems, Kelly; Metzendorf, Maria-Inti; Benstoem, Carina; Stegemann, Miriam

Background At the end of 2021, the European Medicines Agency (EMA) expanded its approval for the recombinant human interleukin‑1 (IL‑1) receptor antagonist Anakinra for the treatment of COVID‑19 patients with elevated ...

2023-10Zeitschriftenartikel

Serologische Untersuchung von Blutspenden auf Antikörper gegen SARS-CoV-2 (SeBluCo- Studie) – Blutspendedienste unterstützen die Pandemieüberwachung

Offergeld, Ruth; Preußel, Karina; an der Heiden, Matthias

Blutspendeproben können die SARS-CoV-2-Serosurveillance unterstützen, um Maßnahmen zur Infektionskontrolle anzupassen. In einer wiederholten Querschnittsstudie von April 2020 bis April 2021, September 2021 und April / ...

2023-02-01Berichte und sonstige Texte

Genetic Organization of Acquired Antimicrobial Resistance Genes and Detection of Resistance-Mediating Mutations in a Gallibacterium anatis Isolate from a Calf Suffering from a Respiratory Tract Infection

Schink, Anne-Kathrin; Hanke, Dennis; Semmler, Torsten; Roschanski, Nicole; Schwarz, Stefan

Gallibacterium (G.) anatis isolates associated with respiratory diseases in calves and har- boring acquired antimicrobial resistance genes have been described in Belgium. The aim of this study was to analyze the genetic ...

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