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2012-08-31Zeitschriftenartikel

Metagenomic abundance estimation and diagnostic testing on species level

Lindner, Martin S.; Renard, Bernhard Y.

One goal of sequencing-based metagenomic community analysis is the quantitative taxonomic assessment of microbial community compositions. In particular, relative quantification of taxons is of high relevance for metagenomic ...

2012-01-30Zeitschriftenartikel

Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals

Pfeifer, Yvonne; Schlatterer, Kathrin; Engelmann, Elisabeth; Schiller, Reinhold A.; Frangenberg, Hans Reiner; Stiewe, Doris; Holfelder, Martin; Witte, Wolfgang; Nordmann, Patrice; Poirel, Laurent

Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is ...

2011-11-30Zeitschriftenartikel

Genome analysis of bat adenovirus 2: Indications of interspecies transmission

Kohl, Claudia; Vidovszky, Márton Z.; Mühldorfer, Kristin; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Wibbelt, Gudrun; Kurth, Andreas; Harrach, Balázs

The genome of bat adenovirus 2 was sequenced and analyzed. It is similar in size (31,616 bp) to the genomes of bat adenovirus 3 and canine adenoviruses 1 and 2. These four viruses are monophyletic and share an identical ...

2012-01-18Zeitschriftenartikel

Evaluation of adding a second marker to overcome Staphylococcus aureus spa-typing homoplasies

Basset, P.; Nübel, Ulrich; Witte, Wolfgang; Blanc, D. S.

The utility of sequencing a second highly variable locus in addition to the spa gene (e.g., double-locus sequence typing [DLST]) was investigated to overcome limitations of a Staphylococcus aureus single-locus typing method. ...

2011-12-09Zeitschriftenartikel

Absence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex CC398 as a Nasal Colonizer of Pigs Raised in an Alternative System

Cuny, Christiane; Friedrich, Alexander W.; Witte, Wolfgang

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) ST398 isolated from pigs raised in conventional farms was previously reported. Here we report a study on 25 farms adhering to an alternative system. ...

2010-11-10Zeitschriftenartikel

The Presence of a vpu Gene and the Lack of Nef-Mediated Downmodulation of T Cell Receptor-CD3 Are Not Always Linked in Primate Lentiviruses

Schmökel, Jan; Sauter, Daniel; Schindler, Michael; Leendertz, Fabian; Bailes, Elizabeth; Dazza, Marie-Christine; Saragosti, Sentob; Bibollet-Ruche, Frederic; Peeters, Martine; Hahn, Beatrice H.; Kirchhoff, Frank

Nef is an accessory protein critical for the ability of human and simian immunodeficiency viruses (HIV and SIV) to replicate efficiently in their respective hosts. Previous analyses of members of 15 different primate ...

2010-05-04Zeitschriftenartikel

Isotopologue Profiling of Legionella pneumophila

Role of Serine and Glucose as Carbon Substrates

Eylert, Eva; Herrmann, Vroni; Jules, Matthieu; Gillmaier, Nadine; Lautner, Monika; Buchrieser, Carmen; Eisenreich, Wolfgang; Heuner, Klaus

Legionella pneumophila (Lp) is commonly found in freshwater habitats but is also the causative agent of Legionnaires' disease when infecting humans. Although various virulence factors have been reported, little is known ...

2010-09-24Zeitschriftenartikel

Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics.

Lasch, Peter; Drevinek, Michal; Nattermann, Herbert; Grunow, Roland; Stämmler, Maren; Dieckmann, Ralf; Schwecke, Torsten; Naumann, Dieter

Yersinia are Gram-negative, rod-shaped facultative anaerobes, and some of them, Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis, are pathogenic in humans. Rapid and accurate identification of ...

2010-05-04Zeitschriftenartikel

Bestimmung von Impfquoten und Inzidenzen von Erkrankungen anhand von Daten der Kassenärztlichen Vereinigungen

Determination of Vaccination Coverage and Disease Incidence using Statutory Health Insurance Data

Reuss, Annicka; Feig, Marcel; Kappelmayer, Lutz; Eckmanns, Tim; Poggensee, Gabriele

Hintergrund: Im Rahmen des KV-Sentinels, einem gemeinsamen Projekt des Robert Koch-Instituts und der 17 Kassenärztlichen Vereinigungen, werden seit 2004 pseudonymisierte Abrechnungsdaten von den Kassenärztlichen Vereinigungen ...

2010-05-24Zeitschriftenartikel

Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis

Frey, Oliver; Meisel, Juliane; Hutloff, Andreas; Bonhagen, Kerstin; Bruns, Lisa; Kroczek, Richard; Morawietz, Lars; Kamradt, Thomas

Objectives: Inducible costimulator (ICOS) and its ligand (ICOSL) regulate T and B cell responses. Glucose-6-phosphate isomerase (G6PI)-induced arthritis requires T and B lymphocytes. It was hypothesised that blocking ...

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