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2011-01-01Zeitschriftenartikel

Towards an AIDS vaccine: The transmembrane envelope protein as target for broadly neutralizing antibodies

Denner, Joachim

Although the development of an effective vaccine is the main goal in the fight against AIDS, all attempts by numerous laboratories to develop a vaccine have failed so far. In addition, it is still unclear whether cytotoxic ...

2011-09-14Zeitschriftenartikel

Influenza B Virus With Modified Hemagglutinin Cleavage Site as a Novel Attenuated Live Vaccine

Stech, Jürgen; Garn, Holger; Herwig, Astrid; Stech, Olga; Dauber, Bianca; Wolff, Thorsten; Mettenleiter, Thomas C.; Klenk, Hans-Dieter

Background: Both pandemic and interpandemic influenza is associated with high morbidity and mortality worldwide. Seasonal epidemics are caused by both influenza A and B virus strains that cocirculate with varying predominance ...

2011-02-01Zeitschriftenartikel

Regional differences in body fat distributions among people with comparable body mass index: a comparison across six German population-based surveys

Stang, Andreas; Döring, Angela; Völzke, Henry; Moebus, Susanne; Greiser, Karin Halina; Werdan, Karl; Berger, Klaus; Ellert, Ute; Neuhauser, Hannelore

Introduction: The mortality of circulatory diseases of the German population varies considerably across regions. The comparison of the regional distributions of cardiovascular risk factors can provide clues to the reasons ...

2009-11-18Zeitschriftenartikel

Deletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency

Sandford, Gordon R.; Schumacher, Uwe; Ettinger, Jakob; Brune, Wolfram; Hayward, Gary S.; Burns, William H.; Voigt, Sebastian

The immediate-early 1 (IE1) and IE2 proteins encoded by the major immediate-early (MIE) transcription unit of cytomegaloviruses are thought to play key roles in the switch between latent- and lytic-cycle infection. Whilst ...

2012-10-01Zeitschriftenartikel

Hepatitis E Virus Seroprevalence among Adults, Germany

Faber, Mirko; Wenzel, Jürgen J.; Jilg, Wolfgang; Thamm, Michael; Höhle, Michael; Stark, Klaus

We assessed hepatitis E virus (HEV) antibody seroprevalence in a sample of the adult population in Germany. Overall HEV IgG prevalence was 16.8% (95% CI 15.6%–17.9%) and increased with age, leveling off at >60 years ...

2012-05-08Zeitschriftenartikel

Blood pressure and lipid management fall far short in persons with type 2 diabetes: results from the DIAB-CORE Consortium including six German population-based studies

Rückert, Ina-Maria; Schunk, Michaela; Holle, Rolf; Schipf, Sabine; Völzke, Henry; Kluttig, Alexander; Greiser, Karin-Halina; Berger, Klaus; Müller, Grit; Ellert, Ute; Neuhauser, Hannelore; Rathmann, Wolfgang; Tamayo, Teresa; Moebus, Susanne; Andrich, Silke; Meisinger, Christa

Background: Although most deaths among patients with type 2 diabetes (T2D) are attributable to cardiovascular disease, modifiable cardiovascular risk factors appear to be inadequately treated in medical practice. The ...

2012-08-13Zeitschriftenartikel

Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1

Morozov, Vladimir; Morozov, Alexey V.; Semaan, Marwan; Denner, Joachim

Background: The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation ...

2011-10-22Zeitschriftenartikel

Das Zentrum für Krebsregisterdaten (ZfKD) im Robert Koch-Institut (RKI) in Berlin

Wolf, Ute; Barnes, Benjamin; Bertz, Joachim; Haberland, Jörg; Laudi, Antje; Stöcker, Manuela; Schönfeld, Ina; Kraywinkel, Klaus; Kurth, Bärbel-Maria

Krebserkrankungen stellen in Deutschland die zweithäufigste Todesursache dar. Zur Beschreibung der Krebsbelastung in der deutschen Bevölkerung ist die Erhebung und Auswertung von Daten über Auftreten und Häufigkeiten von ...

2012-09-27Zeitschriftenartikel

Confidence-based Somatic Mutation Evaluation and Prioritization

Löwer, Martin; Renard, Bernhard Y.; Graaf, Jos de; Wagner, Meike; Paret, Claudia; Kneip, Christoph; Türeci, Özlem; Diken, Mustafa; Britten, Cedrik; Kreiter, Sebastian; Koslowski, Michael; Castle, John C.; Sahin, Ugur

Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms. However, NGS-based somatic mutation ...

2011-10-22Zeitschriftenartikel

Healthcare-associated infections in long-term care facilities (HALT)

Ergebnisse aus Deutschland im Rahmen einer europäischen Prävalenzstudie

Wischnewski, Nicoletta; Mielke, Martin; Wendt, Constanze

Die Ursachen für die Entstehung von Infektionen bei alten Menschen, die in Heimen leben, sind vielfältig. Die oftmals daraus resultierende Antibiotikatherapie kann zudem zu einer Selektion multiresistenter Erreger führen ...

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