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2014-10-27Zeitschriftenartikel

Interrelationship between type three secretion system and metabolism in pathogenic bacteria

Wilharm, Gottfried; Heider, Christine

Before the advent of molecular biology methods, studies of pathogens were dominated by analyses of their metabolism. Development of molecular biology techniques then enabled the identification and functional characterisation ...

2014-09-19Zeitschriftenartikel

Entwicklung der Krankheitslast in Deutschland

Ergebnisse, Potenziale und Grenzen der Global Burden of Disease-Studie

Plass, Dietrich; Vos, Theo; Hornberg, Claudia; Scheidt-Nave, Christa; Zeeb, Hajo; Krämer, Alexander

Hintergrund: Um umfassend und standardisiert die Gesundheit von Bevölkerungen bewerten zu können, wird die Global Burden of Disease (GBD)-Studie durchgeführt. Hierbei werden verlorene Lebenszeit sowie gesundheitliche ...

2014-07-25Zeitschriftenartikel

Xenotransplantation-Progress and Problems: A Review

Denner, Joachim

Xenotransplantation using pig cells, tissues or organs is considered to be a solution to the shortage of human allotransplants. Pigs have been selected as optimal donor for several reasons, among them physiological and ...

2014-09-01Zeitschriftenartikel

Hepatitis E in Deutschland – eine unterschätzte Infektionskrankheit

Pischke, Sven; Behrendt, Patrick; Bock, Thomas; Jilg, Wolfgang; Manns, Michael P.; Wedemeyer, Heiner

Hintergrund: Mindestens 17 % der in Deutschland lebenden Bevölkerung haben eine Infektion mit dem Hepatitis-E-Virus (HEV) durchgemacht. Somit ist diese Infektion in Deutschland häufiger als bislang angenommen. Demgegenüber ...

2014-12-02Zeitschriftenartikel

CMV-Promoter Driven Codon-Optimized Expression Alters the Assembly Type and Morphology of a Reconstituted HERV-K(HML-2)

Hohn, Oliver; Hanke, Kirsten; Lausch, Veronika; Zimmermann, Anja; Mostafa, Saeed; Bannert, Norbert

The HERV-K(HML-2) family contains the most recently integrated and best preserved endogenized proviral sequences in the human genome. All known elements have nevertheless been subjected to mutations or deletions that render ...

2014-11-13Zeitschriftenartikel

Complete Nucleotide Sequence of a Citrobacter freundii Plasmid Carrying KPC-2 in a Unique Genetic Environment

Yao, Yancheng; Imirzalioglu, Can; Hain, Torsten; Kaase, Martin; Gatermann, Soeren; Exner, Martin; Mielke, Martin; Hauri, Anja M.; Dragneva, Yolanta; Bill, Rita; Wendt, Constanze; Wirtz, Angela; Domann, Eugen; Chakraborty, Trinad

The complete and annotated nucleotide sequence of a 54,036-bp plasmid harboring a blaKPC-2 gene that is clonally present in Citrobacter isolates from different species is presented. The plasmid belongs to incompatibility ...

2013-11-24Zeitschriftenartikel

Sexuelle und reproduktive Gesundheit

Tönnies, Holger; Schaade, Lars

2015-04-10Zeitschriftenartikel

Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis

Mikalsen, Theresa; Pedersen, Torunn; Willems, Rob; Coque, Teresa M.; Werner, Guido; Sadowy, Ewa; Schaik, Willem van; Jensen, Lars Bogø; Sundsfjord, Arnfinn; Hegstad, Kristin

Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance ...

2015-06-05Zeitschriftenartikel

Systematic review of models assessing the economic value of routine varicella and herpes zoster vaccination in high-income countries

Damm, Oliver; Ultsch, Bernhard; Horn, Johannes; Mikolajczyk, Rafael T.; Greiner, Wolfgang; Wichmann, Ole

Background: A systematic review was conducted to assess the cost-effectiveness of routine varicella and herpes zoster (HZ) vaccination in high-income countries estimated by modelling studies. Methods: A PubMed search ...

2015-04-28Zeitschriftenartikel

The European I-MOVE Multicentre 2013–2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2)

Valenciano, Marta; Kissling, Esther; Reuss, Annicka; Jiménez-Jorge, Silvia; Horváth, Judit K.; Donnell, Joan M.O.; Pitigoi, Daniela; Machado, Ausenda; Pozo, Francisco

Background: In the first five I-MOVE (Influenza Monitoring Vaccine Effectiveness in Europe) influenza seasons vaccine effectiveness (VE) results were relatively homogenous among participating study sites. In 2013–2014, ...

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