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Now showing items 401-410 of 11373

2014-06-10Zeitschriftenartikel

Leishmania spp. proteome data sets: a comprehensive resource for vaccine development to target visceral leishmaniasis

Aebischer, Toni

Visceral leishmaniasis is a neglected infectious disease caused primarily by Leishmania donovani and Leishmania infantum protozoan parasites. A significant number of infections take a fatal course. Drug therapy is available ...

2014-07-28Zeitschriftenartikel

Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα

Becker, Martina; Güttler, Steffen; Bachem, Annabell; Hartung, Evelyn; Mora, Ahmed; Jäkel, Anika; Hutloff, Andreas; Henn, Volker; Mages, Hans Werner; Gurka, Stephanie; Kroczek, Richard

In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor ...

2013-06-05Zeitschriftenartikel

Segmentation of Confocal Raman Microspectroscopic Imaging Data Using Edge-Preserving Denoising and Clustering

Alexandrov, Theodore; Lasch, Peter

Over the past decade, confocal Raman microspectroscopic (CRM) imaging has matured into a useful analytical tool to obtain spatially resolved chemical information on the molecular composition of biological samples and has ...

2013-06-10Zeitschriftenartikel

Multilocus sequence typing of Scedosporium apiospermum and Pseudallescheria boydii isolates from cystic fibrosis patients

Bernhardt, Anne; Sedlacek, L.; Wagner, S.; Schwarz, C.; Würstl, B.; Tintelnot, Kathrin

Background: Scedosporium and Pseudallescheria species are the second most common lung-colonising fungi in cystic fibrosis (CF) patients. For epidemiological reasons it is important to trace sources of infection, routes ...

2013-07-16Zeitschriftenartikel

Kryptokokkose: Kasuistiken, Epidemiologie und Therapiestrategien

Mischnik, A.; Klein, S.; Tintelnot, Kathrin; Zimmermann, S.; Rickerts, Volker

Die Kryptokokkose ist eine Pilzinfektion, die meist durch Cryptococcus neoformans verursacht wird. Neben den seltener werdenden Erkrankungen bei HIV-Infizierten werden zunehmend Fälle bei anderen Patientenkollektiven wie ...

2013-06-29Zeitschriftenartikel

Dormancy Associated Translation Inhibitor (DATIN/Rv0079) of Mycobacterium tuberculosis interacts with TLR2 and induces proinflammatory cytokine expression

Kumar, Ashutosh; Lewin, Astrid; Rani, Pittu Sandhya; Qureshi, Insaf A.; Devi, Savita; Majid, Mohammad; Kamal, Elisabeth; Marek, Stefanie; Hasnain, Seyed E.; Ahmed, Niyaz

Mycobacterium tuberculosis, the cause of tuberculosis in humans, is present approximately in one third of the world’s population, mostly in a dormant state. The proteins encoded by the dormancy survival regulon (DosR ...

2015-03-12Zeitschriftenartikel

Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40

Zischka, Melanie; Künne, Carsten T.; Blom, Jochen; Wobser, Dominique; Sakιnç, Türkân; Schmidt-Hohagen, Kerstin; Dabrowski, Piotr Wojtek; Nitsche, Andreas; Hübner, Johannes; Hain, Torsten; Chakraborty, Trinad; Linke, Burkhard; Goesmann, Alexander; Voget, Sonja; Daniel, Rolf; Schomburg, Dietmar; Hauck, Rüdiger; Hafez, Hafez M.; Tielen, Petra; Bender, Jennifer K.; Steglich, Matthias; Nübel, Ulrich; Witte, Wolfgang; Werner, Guido

Background: Enterococcus faecalis is a multifaceted microorganism known to act as a beneficial intestinal commensal bacterium. It is also a dreaded nosocomial pathogen causing life-threatening infections in hospitalised ...

2015-02-12Zeitschriftenartikel

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

Desimmie, Belete Ayele; Weydert, Caroline; Schrijvers, Rik; Vets, Sofie; Demeulemeester, Jonas; Proost, Paul; Paron, Igor; Rijck, Jan de; Mast, Jan; Bannert, Norbert; Gijsbers, Rik; Christ, Frauke; Debyser, Zeger

Background: The dynamic interaction between HIV and its host governs the replication of the virus and the study of the virus-host interplay is key to understand the viral lifecycle. The host factor lens epithelium-derived ...

2015-03-17Zeitschriftenartikel

From pills to patients: an evaluation of data sources to determine the number of people living with HIV who are receiving antiretroviral therapy in Germany

Schmidt, Daniel; Kollan, Christian; Stoll, Matthias; Stellbrink, Hans-Jürgen; Plettenberg, Andreas; Fätkenheuer, Gerd; Bergmann, Frank; Bogner, Johannes R.; Lunzen, Jan van; Rockstroh, Jürgen; Esser, Stefan; Jensen, Björn-Erik Ole; Horst, Heinz-August; Fritzsche, Carlos; Kühne, Andrea; Heiden, Matthias an der; Hamouda, Osamah; Bartmeyer, Barbara

Background: This study aimed to determine the number of people living with HIV receiving antiretroviral therapy (ART) between 2006 and 2013 in Germany by using the available numbers of antiretroviral drug prescriptions ...

2015-03-14Zeitschriftenartikel

‘We can do only what we have the means for’ general practitioners’ views of primary care for older people with complex health problems

Herzog, Anna; Gaertner, Beate; Scheidt-Nave, Christa; Holzhausen, Martin

Background: Due to demographic change, general practitioners (GPs) are increasingly required to care for older people with complex health problems. Little is known about the subjective appraisals of GPs concerning the ...

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