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2015-02-26Zeitschriftenartikel

IPred - integrating ab initio and evidence based gene predictions to improve prediction accuracy

Zickmann, Franziska; Renard, Bernhard Y.

Background: Gene prediction is a challenging but crucial part in most genome analysis pipelines. Various methods have evolved that predict genes ab initio on reference sequences or evidence based with the help of ...

2014-06-05Zeitschriftenartikel

Saving Human Lives: What Complexity Science and Information Systems can Contribute

Helbing, Dirk; Brockmann, Dirk; Chadefaux, Thomas; Donnay, Karsten; Blanke, Ulf; Woolley-Meza, Olivia; Moussaid, Mehdi; Johansson, Anders; Krause, Jens; Schutte, Sebastian; Perc, Matjaž

We discuss models and data of crowd disasters, crime, terrorism, war and disease spreading to show that conventional recipes, such as deterrence strategies, are often not effective and sufficient to contain them. Many ...

2013-10-24Zeitschriftenartikel

Background paper to the revised recommendation for hepatitis B vaccination of persons at particular risk and for hepatitis B postexposure prophylaxis in Germany

Harder, Thomas; Remschmidt, Cornelius; Falkenhorst, Gerhard; Zimmermann, Ruth; Hengel, Hartmut; Ledig, Thomas; Oppermann, Hanna; Zeuzem, S.; Wicker, Sabine

Die Ständige Impfkommission (STIKO) empfiehlt die Impfung von Risikogruppen gegen Hepatitis B (Indikationsimpfung) und die Postexpositionsprophylaxe. Diese Empfehlung wurde überarbeitet, unter Fokussierung auf i) die ...

2013-10-24Zeitschriftenartikel

Background paper to the recommendation for the preferential use of live-attenuated influenza vaccine in children aged 2–6 years in Germany

Falkenhorst, Gerhard; Harder, Thomas; Remschmidt, Cornelius; Terhardt, Martin; Zepp, Fred; Ledig, Thomas; Wicker, Sabine; Keller-Stanislawski, B.; Mertens, Thomas

Die Ständige Impfkommission (STIKO) empfiehlt die saisonale Influenza-Impfung für Kinder und Jugendliche mit chronischen Krankheiten, die ein erhöhtes Risiko für eine schwere Erkrankung an Influenza mit sich bringen. Neben ...

2013-10-09Zeitschriftenartikel

Cryo FIB-SEM: Volume imaging of cellular ultrastructure in native frozen specimens

Schertel, Andreas; Snaidero, Nicolas; Han, Hong-Mei; Ruhwedel, Torben; Laue, Michael; Grabenbauer, Markus; Möbius, Wiebke

Volume microscopy at high resolution is increasingly required to better understand cellular functions in the context of three-dimensional assemblies. Focused ion beam (FIB) milling for serial block face imaging in the ...

2014-09-04Zeitschriftenartikel

Measles virus spread initiated at international mass gatherings in Europe, 2011

Santibanez, Sabine; Prosenc, K.; Lohr, D.; Pfaff, Günter; Markocic, O. Jordan; Mankertz, Annette

Three parallel transmission chains of measles virus (MV) variant ‘D8-Villupuram’ (D8-V) originated from two coinciding international mass gathering (MG) events in Rimini, Italy, in June 2011. MV D8-V was independently ...

2012-04-23Zeitschriftenartikel

The mglA gene and its flanking regions in Brucella: The role of mglA in tolerance to hostile environments, Fe-metabolism and in vivo persistence

Jacob, Jens; Finke, Antje; Mielke, Martin

We previously demonstrated that a spontaneous smooth small-colony variant of Brucella abortus S19 is characterized by increased in vivo persistence and the differential expression of a gene predicted to encode a galactoside ...

2014-10-20Zeitschriftenartikel

Malaria parasite detection increases during pregnancy in wild chimpanzees

Nys, Hélène M. de; Calvignac-Spencer, Sébastien; Boesch, Christophe; Dorny, Pierre; Wittig, Roman M.; Mundry, Roger; Leendertz, Fabian

Background: The diversity of malaria parasites (Plasmodium sp.) infecting chimpanzees (Pan troglodytes) and their close relatedness with those infecting humans is well documented. However, their biology is still largely ...

2014-10-25Zeitschriftenartikel

Decontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates

Thomzig, Achim; Wagenführ, Katja; Daus, Martin L.; Joncic, Marion; Schulz-Schaeffer, Walter J.; Thanheiser, Marc; Mielke, Martin; Beekes, Michael

2014-10-01Zeitschriftenartikel

Some Notes on Critical Appraisal of Prevalence Studies; Comment on: “The Development of a Critical Appraisal Tool for Use in Systematic Reviews Addressing Questions of Prevalence”

Decisions in healthcare should be based on information obtained according to the principles of Evidence-Based Medicine (EBM). An increasing number of systematic reviews are published which summarize the results of prevalence ...

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