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2018-07-19Zeitschriftenartikel

A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential

Grund, Christian; Hoffmann, Donata; Ulrich, Reiner; Naguib, Mahmoud; Schinköthe, Jan; Hoffmann, Bernd; Harder, Timm; Saenger, Sandra; Zscheppang, Katja; Tönnies, Mario; Hippenstiel, Stefan; Hocke, Andreas; Wolff, Thorsten; Beer, Martin

We investigated in a unique setup of animal models and a human lung explant culture biological properties, including zoonotic potential, of a representative 2016 highly pathogenic avian influenza virus (HPAIV) H5N8, clade ...

2019-03-19Zeitschriftenartikel

A Novel Orthohepadnavirus Identified in a Dead Maxwell’s Duiker (Philantomba maxwellii) in Taï National Park, Côte d’Ivoire

Gogarten, Jan F.; Ulrich, Markus; Bhuva, Nishit; Garcia, Joel; Jain, Komal; Lee, Bohyun; Löhrich, Therese; Oleynik, Alexandra; Couacy-Hymann, Emmanuel; Fuh Neba, Terence; Mishra, Nischay; Briese, Thomas; Calvignac-Spencer, Sébastien; Lipkin, W. Ian; Leendertz, Fabian H.

New technologies enable viral discovery in a diversity of hosts, providing insights into viral evolution. We used one such approach, the virome capture sequencing for vertebrate viruses (VirCapSeq-VERT) platform, on 21 ...

2019-03-13Zeitschriftenartikel

Hepatitis E virus (HEV)—The Future

Denner, Joachim

Hepatitis (HEV) is widely distributed in pigs and is transmitted with increasing numbers to humans by contact with pigs, contaminated food and blood transfusion. The virus is mostly apathogenic in pigs but may enhance the ...

2018-11-15Zeitschriftenartikel

Antimicrobial resistance of Escherichia coli isolates from outpatient urinary tract infections in women in six European countries including Russia

Ny, Sofia; Edquist, Petra; Dumpis, Uga; Gröndahl-Yli-Hannuksela, Kirsi; Hermes, Julia; Kling, Anna-Maria; Klingeberg, Anja; Kozlov, Roman; Källman, Owe; Lis, Danuta O.; Pomorska-Wesołowska, Monika; Saule, Mära; Tegmark Wisell, Karin; Vuopio, Jaana; Palagin, Ivan; NoDARS UTIStudy Group

Objectives In the Northern Dimension Antibiotic Resistance Study (NoDARS), Finland, Germany, Latvia, Poland, Russia and Sweden collected urine samples from outpatient women (aged 18–65 years) with symptoms of uncomplicated ...

2018-07-19Zeitschriftenartikel

Recent Trends in Research with Human Pluripotent Stem Cells: Impact of Research and Use of Cell Lines in Experimental Research and Clinical Trials

Guhr, Anke; Kobold, Sabine; Seltmann, Stefanie; Seiler Wulczyn, Andrea E. M.; Kurtz, Andreas; Löser, Peter

The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. To assess possible novel trends in hPSC usage, we analyzed experimental hPSC research published from 2014 to 2016 and compared our data with ...

2018-11-12Zeitschriftenartikel

Hepatitis A virus infections, immunisations and demographic determinants in children and adolescents, Germany

Michaelis, Kai; Poethko-Müller, Christina; Kuhnert, Ronny; Stark, Klaus; Faber, Mirko

Hepatitis A is a vaccine-preventable disease with a global distribution. It predominantly occurs in regions with inadequate living conditions, but also affects populations in industrialised countries. Children are frequently ...

2018-10-14Zeitschriftenartikel

Determinants of Change in Glycemic Status in Individuals with Prediabetes: Results from a Nationwide Cohort Study in Germany

Paprott, Rebecca; Scheidt-Nave, Christa; Heidemann, Christin

Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to ...

2018-10-04Zeitschriftenartikel

Surveillance on speed: Being aware of infectious diseases in migrants mass accommodations - an easy and flexible toolkit for field application of syndromic surveillance, Germany, 2016 to 2017

Sarma, Navina; Ullrich, Alexander; Wilking, Hendrik; Ghozzi, Stéphane; Lindner, Andreas K.; Weber, Christoph; Holzer, Alexandra; Jansen, Andreas; Stark, Klaus; Vygen-Bonnet, Sabine

Europe received an increased number of migrants in 2015. Housing in inadequate mass accommodations (MA) made migrants prone to infectious disease outbreaks. In order to enhance awareness for infectious diseases (ID) and ...

2019-03-06Zeitschriftenartikel

Diagnosing Zika virus infection against a background of other flaviviruses: Studies in high resolution serological analysis

Hansen, Sören; Hotop, Sven-Kevin; Faye, Oumar; Ndiaye, Oumar; Böhlken-Fascher, Susanne; Pessôa, Rodrigo; Hufert, Frank; Stahl-Hennig, Christiane; Frank, Roland; Czerny, Claus-Peter; Schmidt-Chanasit, Jonas; Sanabani, Sabri S.; Sall, Amadou A.; Niedrig, Matthias; Brönstrup, Mark; Fritz, Hans-Joachim; Abd El Wahed, Ahmed

Zika virus (ZIKV) is a mosquito-borne flavivirus. Homologous proteins of different flaviviruses display high degrees of sequence identity, especially within subgroups. This leads to extensive immunological cross-reactivity ...

2019-03-06Zeitschriftenartikel

Telbivudine Reduces Parvovirus B19-Induced Apoptosis in Circulating Angiogenic Cells

Zobel, Thomas; Bock, C. Thomas; Kühl, Uwe; Rohde, Maria; Lassner, Dirk; Schultheiss, Heinz-Peter; Schmidt-Lucke, Caroline

Aims: Human parvovirus B19 (B19V) infection directly induces apoptosis and modulates CXCR4 expression of infected marrow-derived circulating angiogenic cells (CACs). This leads to dysfunctional endogenous vascular repair. ...

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