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2017-06-21Zeitschriftenartikel

Differential Substrate Usage and Metabolic Fluxes in Francisella tularensis Subspecies holarctica and Francisella novicida

Chen, Fan; Rydzewski, Kerstin; Kutzner, Erika; Häuslein, Ina; Schunder, Eva; Wang, Xinzhe; Meighen-Berger, Kevin; Grunow, Roland; Eisenreich, Wolfgang; Heuner, Klaus

Francisella tularensis is an intracellular pathogen for many animals causing the infectious disease, tularemia. Whereas F. tularensis subsp. holarctica is highly pathogenic for humans, F. novicida is almost avirulent for ...

2017-07-11Zeitschriftenartikel

Surveillance of recent HIV infections among newly diagnosed HIV cases in Germany between 2008 and 2014

Hofmann, Alexandra; Hauser, Andrea; Zimmermann, Ruth; Santos-Hövener, Claudia; Bätzing-Feigenbaum, Jörg; Wildner, Stephan; Kücherer, Claudia; Bannert, Norbert; Hamouda, Osamah; Bremer, Viviane; Bartmeyer, Barbara

Background: The HIV surveillance system in Germany is based on mandatory, anonymous notification of newly diagnosed HIV cases by laboratories. Because the time between HIV infection and the diagnosis of HIV varies widely ...

2015-06-24Zeitschriftenartikel

Ebola Virus Disease Outbreak in Isiro, Democratic Republic of the Congo, 2012: Signs and Symptoms, Management and Outcomes

Kratz, Thomas; Roddy, Paul; Oloma, Antoine Tshomba; Jeffs, Benjamin; Ciruelo, Diana Pou; Rosa, Olimpia de la; Borchert, Matthias

Data collected during the 2012 Ebola virus disease (EVD) epidemic in the Democratic Republic of the Congo were analysed for clinical signs, symptoms and case fatality of EVD caused by Bundibugyo virus (BDBV), establishment ...

2017-07-03Zeitschriftenartikel

Parents with mental health problems and their children in a German population based sample: Results of the BELLA study

Plass-Christl, Angela; Haller, Anne-Catherine; Otto, Christiane; Barkmann, Claus; Wiegand-Grefe, Silke; Hölling, Heike; Schulte-Markwort, Michael; Ravens-Sieberer, Ulrike; Klasen, Fionna

Background: Mental health problems (MHP) of parents are associated with an increased risk of psychological and developmental difficulties in their children. This study aims at analyzing population-based data of parents ...

2017-06-30Zeitschriftenartikel

Establishing an ICD-10 code based SARI-surveillance in Germany – description of the system and first results from five recent influenza seasons

Buda, Silke; Tolksdorf, Kristin; Schuler, E.; Kuhlen, R.; Haas, Walter

Background: Syndromic surveillance of severe acute respiratory infections (SARI) is important to assess seriousness of disease as recommended by WHO for influenza. In 2015 the Robert Koch Institute (RKI) started to ...

2017-07-06Zeitschriftenartikel

Legionnaires’ disease in Europe, 2011 to 2015

Beauté, Julien

Under the coordination of the European Centre for Disease Prevention and Control (ECDC), the European Legionnaires’ disease Surveillance Network (ELDSNet) conducts surveillance of Legionnaires’ disease (LD) in Europe. ...

2016-02-01Zeitschriftenartikel

Beekes, Michael

2016-06-16Zeitschriftenartikel

Only the complex N559-glycan in SV2C mediates high affinity binding to botulinum neurotoxin serotype A1

Mahrhold, Stefan; Bergström, Tomas; Stern, Daniel; Dorner, Brigitte; Astot, Crister; Rummel, Andreas

The extraordinary potency of botulinum neurotoxins (BoNTs) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid paralysis and successive respiratory failure. Complex ...

2016-10-08Zeitschriftenartikel

Psychotropic drug use and alcohol consumption among older adults in Germany: results of the German Health Interview and Examination Survey for Adults 2008–2011

Du, Yong; Wolf, Ingrid-Katharina; Knopf, Hildtraud

Objectives: The use and combined use of psychotropic drugs and alcohol among older adults is a growing public health concern and should be constantly monitored. Relevant studies are scarce in Germany. Using data of the ...

2016-09-22Zeitschriftenartikel

Epidemiological and molecular investigation of a rubella outbreak, Romania, 2011 to 2012

Lazar, M.; Abernathy, E.; Chen, M.; Icenogle, J.; Janta, D.; Stanescu, A.; Pistol, A.; Santibanez, Sabine; Mankertz, Annette; Hübschen, Judith M.; Mihaescu, G.; Necula, Gheorghe; Lupulescu, E.

We describe a rubella outbreak that occurred in Romania between September 2011 and December 2012. During this period 24,627 rubella cases, 41.1% (n=10,134) of which female, were notified based on clinical criteria, and a ...

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