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2022-01-24Zeitschriftenartikel
Longitudinal SARS-CoV-2 seroepidemiological investigation among healthcare workers at a tertiary care hospital in Germany
dc.contributor.authorTomczyk, Sara
dc.contributor.authorHönning, Alexander
dc.contributor.authorHermes, Julia
dc.contributor.authorGrossegesse, Marica
dc.contributor.authorHofmann, Natalie
dc.contributor.authorMichel, Janine
dc.contributor.authorNeumann, Markus
dc.contributor.authorNitsche, Andreas
dc.contributor.authorHoppe, Berthold
dc.contributor.authorEckmanns, Tim
dc.contributor.authorSchmidt‑Traub, Hajo
dc.contributor.authorZappel, Kristina
dc.date.accessioned2022-08-17T06:38:25Z
dc.date.available2022-08-17T06:38:25Z
dc.date.issued2022-01-24none
dc.identifier.other10.1186/s12879-022-07057-3
dc.identifier.urihttp://edoc.rki.de/176904/10052
dc.description.abstractBackground: SARS-CoV-2 cases in Germany increased in early March 2020. By April 2020, cases among health care workers (HCW) were detected across departments at a tertiary care hospital in Berlin, prompting a longitudinal investigation to assess HCW SARS-CoV-2 serostatus with an improved testing strategy and associated risk factors. Methods: In May/June and December 2020, HCWs voluntarily provided blood for serology and nasopharyngeal/oropharyngeal (NP/OP) samples for real-time polymerase chain reaction (PCR) and completed a questionnaire. A four-tiered SARS-CoV-2 serological testing strategy including two different enzyme-linked immunosorbent assays (ELISA) and biological neutralization test (NT) was used. ELISA-NT correlation was assessed using Pearson’s correlation coefficient. Sociodemographic and occupational factors associated with seropositivity were assessed with multivariate logistic regression. Results: In May/June, 18/1477 (1.2%) HCWs were SARS-CoV-2 seropositive, followed by 56/1223 (4.6%) in December. Among those tested in both, all seropositive in May/June remained seropositive by ELISA and positive by NT after 6 months. ELISA ratios correlated well with NT titres in May/June (R = 0.79) but less so in December (R = 0.41). Those seropositive reporting a past SARS-CoV-2 positive PCR result increased from 44.4% in May/June to 85.7% in December. HCWs with higher occupational risk (based on profession and working site), nurses, males, and those self-reporting COVID-19-like symptoms had significantly higher odds of seropositivity. Conclusions: This investigation provides insight into the burden of HCW infection in this local outbreak context and the antibody dynamics over time with an improved robust testing strategy. It also highlights the continued need for effective infection control measures particularly among HCWs with higher occupational risk.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectSARS-CoV-2eng
dc.subjectSeropositivityeng
dc.subjectHealth care workereng
dc.subjectOutbreakeng
dc.subjectTertiary hospitaleng
dc.subjectGermanyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleLongitudinal SARS-CoV-2 seroepidemiological investigation among healthcare workers at a tertiary care hospital in Germanynone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/10052-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleBMC Infectious Diseasesnone
local.edoc.container-issn1471-2334none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07057-3none
local.edoc.container-publisher-nameBioMed Centralnone
local.edoc.container-volume22none
local.edoc.container-issue80none
local.edoc.container-year2022none
dc.description.versionPeer Reviewednone

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