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2022-12Studienarbeit DOI: 10.25646/10827
Epidemiologie und klinischer Verlauf von Thymomen und Thymuskarzinomen
dc.contributor.authorUniversitätsmedizin Mainz
dc.date.accessioned2023-01-05T07:34:41Z
dc.date.available2023-01-05T07:34:41Z
dc.date.issued2022-12none
dc.identifier.urihttp://edoc.rki.de/176904/10574
dc.language.isoundnone
dc.publisherRobert Koch-Institut
dc.relation.isreferencedbyGerber TS, Strobl S, Marx A, Roth W and Porubsky S (2024) Epidemiology of thymomas and thymic carcinomas in the United States and Germany, 1999-2019. Front. Oncol. 13:1308989. doi: 10.3389/fonc.2023.1308989
dc.relation.isreferencedbyIntroduction: Mediastinal tumors, particularly non-neuroendocrine thymic epithelial tumors (TET) are relatively uncommon, posing challenges for extensive epidemiological studies. This study presents a comprehensive analysis of these tumors in the United States (US) and Germany (GER) from 1999 to 2019. Methods: Patients aged 0-19 (n=478) and ≥20 years (n=17,459) diagnosed with malignant tumors of the anterior mediastinum were identified from the Surveillance, Epidemiology, and End Results registry (SEER) and the Zentrum für Krebsregisterdaten (ZfKD) databases. Results: Among patients aged ≥20 years, TETs accounted for the most prevalent anterior mediastinal tumors (US/GER: 63%/64%), followed by lymphomas (14%/ 8%). For patients <20 years, predominant tumors included germ cell tumors (42%/14%), lymphomas (38%/53%), and TETs (10%/27%). The overall annual incidence of thymoma was 2.2/2.64 (US/GER) per million inhabitants and for thymic carcinomas 0.48/0.42. The male-to-female ratio was 1:1.09/1.03, and the mean age 59.48 ± 14.89/61.33 ± 13.94. Individuals with thymomas, but not thymic carcinomas, exhibited a 21%/29% significantly heightened risk of developing secondary malignancies compared to controls with non-thymic primary tumors. Discussion: This study provides a comparative analysis of anterior mediastinal tumors, particularly TETs, in the US and GER over the past two decades. Furthermore, it highlights a significantly elevated incidence of secondary malignancies in thymoma patients.Englisch
dc.relation.isreferencedbyhttps://doi.org/10.3389/fonc.2023.1308989
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleEpidemiologie und klinischer Verlauf von Thymomen und Thymuskarzinomennone
dc.typeStudyThesis
dc.identifier.urnurn:nbn:de:0257-176904/10574-8
dc.identifier.doi10.25646/10827
local.edoc.type-nameStudienarbeit

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