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2023-04-02Zeitschriftenartikel
Monitoring the SARS-CoV-2 Pandemic: Prevalence of Antibodies in a Large, Repetitive Cross-Sectional Study of Blood Donors in Germany—Results from the SeBluCo Study 2020–2022
dc.contributor.authorOffergeld, Ruth
dc.contributor.authorPreußel, Karina
dc.contributor.authorZeiler, Thomas
dc.contributor.authorAurich, Konstanze
dc.contributor.authorBaumann-Baretti, Barbara I.
dc.contributor.authorCiesek, Sandra
dc.contributor.authorCorman, Victor M.
dc.contributor.authorDienst, Viktoria
dc.contributor.authorDrosten, Christian
dc.contributor.authorGörg, Siegfried
dc.contributor.authorGreinacher, Andreas
dc.contributor.authorGrossegesse, Marica
dc.contributor.authorHaller, Sebastian
dc.contributor.authorHeuft, Hans-Gert
dc.contributor.authorHofmann, Natalie
dc.contributor.authorHorn, Peter A.
dc.contributor.authorHouareau, Claudia
dc.contributor.authorGülec, Ilay
dc.contributor.authorJiménez Klingberg, Carlos Luis
dc.contributor.authorJuhl, David
dc.contributor.authorLindemann, Monika
dc.contributor.authorMartin, Silke
dc.contributor.authorNeuhauser, Hannelore K.
dc.contributor.authorNitsche, Andreas
dc.contributor.authorOhme, Julia
dc.contributor.authorPeine, Sven
dc.contributor.authorSachs, Ulrich J.
dc.contributor.authorSchaade, Lars
dc.contributor.authorSchäfer, Richard
dc.contributor.authorScheiblauer, Heinrich
dc.contributor.authorSchlaud, Martin
dc.contributor.authorSchmidt, Michael
dc.contributor.authorUmhau, Markus
dc.contributor.authorVollmer, Tanja
dc.contributor.authorWagner, Franz F.
dc.contributor.authorWieler, Lothar H.
dc.contributor.authorWilking, Hendrik
dc.contributor.authorZiemann, Malte
dc.contributor.authorZimmermann, Marlow
dc.contributor.authoran der Heiden, Matthias
dc.date.accessioned2023-11-27T09:20:34Z
dc.date.available2023-11-27T09:20:34Z
dc.date.issued2023-04-02none
dc.identifier.other10.3390/pathogens12040551
dc.identifier.urihttp://edoc.rki.de/176904/11381
dc.description.abstractSARS-CoV-2 serosurveillance is important to adapt infection control measures and estimate the degree of underreporting. Blood donor samples can be used as a proxy for the healthy adult population. In a repeated cross-sectional study from April 2020 to April 2021, September 2021, and April/May 2022, 13 blood establishments collected 134,510 anonymised specimens from blood donors in 28 study regions across Germany. These were tested for antibodies against the SARS-CoV-2 spike protein and nucleocapsid, including neutralising capacity. Seroprevalence was adjusted for test performance and sampling and weighted for demographic differences between the sample and the general population. Seroprevalence estimates were compared to notified COVID-19 cases. The overall adjusted SARS-CoV-2 seroprevalence remained below 2% until December 2020 and increased to 18.1% in April 2021, 89.4% in September 2021, and to 100% in April/May 2022. Neutralising capacity was found in 74% of all positive specimens until April 2021 and in 98% in April/May 2022. Our serosurveillance allowed for repeated estimations of underreporting from the early stage of the pandemic onwards. Underreporting ranged between factors 5.1 and 1.1 in the first two waves of the pandemic and remained well below 2 afterwards, indicating an adequate test strategy and notification system in Germany.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectSARS-CoV-2eng
dc.subjectCovid-19eng
dc.subjectseroprevalenceeng
dc.subjectCovid 19 serological testingeng
dc.subjectblood donorseng
dc.subjectsurveillanceeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleMonitoring the SARS-CoV-2 Pandemic: Prevalence of Antibodies in a Large, Repetitive Cross-Sectional Study of Blood Donors in Germany—Results from the SeBluCo Study 2020–2022none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11381-4
dc.type.versionpublishedVersionnone
dc.relation.issupplementedbyhttps://doi.org/10.5281/zenodo.10037246
local.edoc.container-titlePathogensnone
local.edoc.container-issn2076-0817none
local.edoc.pages17none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/journal/pathogensnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume12none
local.edoc.container-reportyear2023none
dc.description.versionPeer Reviewednone

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