Show simple item record

2012-08-06Zeitschriftenartikel DOI: 10.1371/journal.pone.0042867
Seroprevalence of Measles-, Mumps- and Rubella-Specific IgG Antibodies in German Children and Adolescents and Predictors for Seronegativity
dc.contributor.authorPoethko-Müller, Christina
dc.contributor.authorMankertz, Annette
dc.date.accessioned2018-05-07T15:46:33Z
dc.date.available2018-05-07T15:46:33Z
dc.date.created2012-08-13
dc.date.issued2012-08-06none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re15j6PmWdS2o/PDF/2384uTuoB5ioU.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1258
dc.description.abstractWe have undertaken a seroprevalence study with more than 13,000 children, who had been included in the German KIGGS survey, a representative sample of children and adolescents 0–17 years of age. The IgG titres against measles, mumps and rubella were determined in 1 to 17 year olds While 88.8% of the children were MMR-vaccinated at least once, 76.8% of children aged 1 to 17 years showed prevalence of antibodies to MMR. The highest seronegativity was seen with respect to mumps. Gender differences were most pronounced with regard to rubella IgG titres: girls aged 14 to 17 years were best protected, although seronegativity in 6.8% of this vulnerable group still shows the need of improvement. Search for predictors of missing seroprevalence identified young age to be the most important predictor. Children living in the former West and children born outside of Germany had a higher risk of lacking protection against measles and rubella, while children with a migration background but born in Germany were less often seronegative to measles antibodies than their German contemporaries. An association of seronegativity and early vaccination was seen for measles but not for mumps and rubella. A high maternal educational level was associated with seronegativity to measles and rubella. In vaccinated children, seronegativity was highest for mumps and lowest for rubella. For mumps, high differences were observed for seronegativity after one-dose and two-dose vaccination, respectively. Seronegativity increases as time since last vaccination passes thus indicating significant waning effects for all three components of MMR.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAdolescenteng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectGermany/epidemiologyeng
dc.subjectMaleeng
dc.subjectRisk Factorseng
dc.subjectChildeng
dc.subjectSeroepidemiologic Studieseng
dc.subjectInfanteng
dc.subjectMultivariate Analysiseng
dc.subjectOdds Ratioeng
dc.subjectMeasles/epidemiologyeng
dc.subjectVaccinationeng
dc.subjectChild Preschooleng
dc.subjectImmunoglobulin G/immunologyeng
dc.subjectAntibodies Viral/immunologyeng
dc.subjectMumps/epidemiologyeng
dc.subjectMeasles/immunologyeng
dc.subjectMeasles-Mumps-Rubella Vaccine/immunologyeng
dc.subjectMumps/immunologyeng
dc.subjectRubella/epidemiologyeng
dc.subjectRubella/immunologyeng
dc.subject.ddc610 Medizin
dc.titleSeroprevalence of Measles-, Mumps- and Rubella-Specific IgG Antibodies in German Children and Adolescents and Predictors for Seronegativity
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10026093
dc.identifier.doi10.1371/journal.pone.0042867
dc.identifier.doihttp://dx.doi.org/10.25646/1183
local.edoc.container-titlePLoS ONE
local.edoc.container-textPoethko-Müller C, Mankertz A (2012) Seroprevalence of Measles-, Mumps- and Rubella-Specific IgG Antibodies in German Children and Adolescents and Predictors for Seronegativity. PLoS ONE 7(8): e42867.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042867
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume7
local.edoc.container-issue8
local.edoc.container-year2012

Show simple item record