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2012-01-01Zeitschriftenartikel DOI: 10.4161/pri.6.1.17776
Chronic wasting disease: Fingerprinting the culprit in risk assessments
dc.contributor.authorDaus, Martin L.
dc.contributor.authorBeekes, Michael
dc.date.accessioned2018-05-07T15:49:08Z
dc.date.available2018-05-07T15:49:08Z
dc.date.created2012-09-04
dc.date.issued2012-01-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reYkQuqqds4M/PDF/20oNZTyNNXg.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1272
dc.description.abstractTransmissible spongiform encephalopathies (prion diseases) in animals may be associated with a zoonotic risk potential for humans as shown by the occurrence of variant Creutzfeldt-Jakob disease in the wake of the bovine spongiform encephalopathy epidemic. Thus, the increasing exposure of humans in North America to cervid prions of chronic wasting disease (CWD) in elk and deer has prompted comprehensive risk assessments. The susceptibility of humans to CWD infections is currently under investigation in different studies using macaques as primate models. The necessity for such studies was recently reinforced when disease-associated prion protein and its seeding activity were detected in muscles of clinically inconspicuous CWD-infected white-tailed deer (WTD). Increasing evidence points to the existence of different CWD strains, and CWD prions may also change or newly emerge over time. Therefore, CWD isolates examined in macaques should be characterized as precisely as possible for their molecular identity. On this basis other CWD field samples collected in the past, present or future could be systematically compared with macaque-tested inocula in order to assess whether they are covered by the ongoing risk assessments in primates. CWD typing by Fourier transform-infrared spectroscopy of pathological prion protein may provide a method of choice for this purpose.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAnimalseng
dc.subjectEnvironmental Exposureeng
dc.subjectHumanseng
dc.subjectRisk Assessmenteng
dc.subjectZoonoses/transmissioneng
dc.subjectSpectroscopy Fourier Transform Infraredeng
dc.subjectWasting Disease Chronic/diagnosis*eng
dc.subject.ddc610 Medizin
dc.titleChronic wasting disease: Fingerprinting the culprit in risk assessments
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10026781
dc.identifier.doi10.4161/pri.6.1.17776
dc.identifier.doihttp://dx.doi.org/10.25646/1197
local.edoc.container-titlePrion
local.edoc.container-textDaus, M.L., Beekes, M. Chronic wasting disease: Fingerprinting the culprit in risk assessments (2012) Prion, 6 (1), pp. 17-22.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.landesbioscience.com/journals/prion/article/17776/
local.edoc.container-publisher-nameLandes Bioscience
local.edoc.container-volume6
local.edoc.container-issue1
local.edoc.container-year2012

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