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2012-09-01Zeitschriftenartikel DOI: 10.25646/1211
Effectiveness and Timing of Vaccination during School Measles Outbreak
dc.contributor.authorMarinović, Axel Antonio Bonačić
dc.contributor.authorSwaan, Corien
dc.contributor.authorWichmann, Ole
dc.contributor.authorSteenbergen, Jim van
dc.contributor.authorKretzschmar, Mirjam
dc.date.accessioned2018-05-07T15:51:45Z
dc.date.available2018-05-07T15:51:45Z
dc.date.created2012-09-10
dc.date.issued2012-09-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/retdxAuBUNHE/PDF/24CD8Y3XWMKA.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1286
dc.description.abstractDespite high vaccination coverage in most European countries, large community outbreaks of measles do occur, normally clustered around schools and resulting from suboptimal vaccination coverage. To determine whether or when it is worth implementing outbreak-response vaccination campaigns in schools, we used stochastic outbreak models to reproduce a public school outbreak in Germany, where no vaccination campaign was implemented. We assumed 2 scenarios covering the baseline vaccination ratio range (91.3%–94.3%) estimated for that school and computed outbreaks assuming various vaccination delays. In one scenario, reacting (i.e., implementing outbreak-response vaccination campaigns) within 12–24 days avoided large outbreaks and reacting within 50 days reduced outbreak size. In the other scenario, reacting within 6–14 days avoided large outbreaks and reacting within 40 days reduced the outbreak size. These are realistic time frames for implementing school outbreak response vaccination campaigns. High baseline vaccination ratios extended the time needed for effective response.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectDisease Outbreakseng
dc.subjectHumanseng
dc.subjectGermany/epidemiologyeng
dc.subjectRetrospective Studieseng
dc.subjectTime Factorseng
dc.subjectMeasles/epidemiologyeng
dc.subjectVaccinationeng
dc.subjectSchoolseng
dc.subjectMeasles/prevention & controleng
dc.subjectModels Theoreticaleng
dc.subjectMeasles Vaccine/immunologyeng
dc.subject.ddc610 Medizin
dc.titleEffectiveness and Timing of Vaccination during School Measles Outbreak
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10026960
dc.identifier.doihttp://dx.doi.org/10.25646/1211
local.edoc.container-titleEmerging Infectious Diseases
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://wwwnc.cdc.gov/eid/article/18/9/11-1578_article.htm
local.edoc.container-publisher-nameCenters for Disease Control and Prevention
local.edoc.container-volume18
local.edoc.container-issue9
local.edoc.container-year2012

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