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2011-10-07Zeitschriftenartikel DOI: 10.1016/j.ijmm.2011.09.007
From types to trees: Reconstructing the spatial spread of Staphylococcus aureus based on DNA variation
dc.contributor.authorNübel, Ulrich
dc.contributor.authorStrommenger, Birgit
dc.contributor.authorLayer, Franziska
dc.contributor.authorWitte, Wolfgang
dc.date.accessioned2018-05-07T16:01:16Z
dc.date.available2018-05-07T16:01:16Z
dc.date.created2012-11-05
dc.date.issued2011-10-07none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re0u2MTl126oA/PDF/23AouIDNEgfA.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1338
dc.description.abstractTracing the spatial spread of pathogens is a key objective of molecular infectious disease epidemiology. Accordingly, a wide range of genotyping approaches have been used to monitor the dissemination of Staphylococcus aureus strains, from localized outbreaks to global spread. We provide a critical review of available methods, revealing that molecular markers currently in use for typing S. aureus acquire changes so slowly that they monitor evolutionary change over timescales that are largely irrelevant to epidemiology. Moreover, the more variable markers frequently do not reflect the pathogen's evolutionary history and, hence, provide potentially misleading information about spread. More recent work has demonstrated that staphylococcal evolution proceeds sufficiently fast that the dynamics of S. aureus spatial spread can be elucidated at great detail on the basis of genome-wide single-nucleotide polymorphisms.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectMRSAeng
dc.subjectPhylogeographyeng
dc.subjectMLSTeng
dc.subjectPFGEeng
dc.subjectspa typingeng
dc.subjectMLVAeng
dc.subjectSNPseng
dc.subject.ddc610 Medizin
dc.titleFrom types to trees: Reconstructing the spatial spread of Staphylococcus aureus based on DNA variation
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10027690
dc.identifier.doi10.1016/j.ijmm.2011.09.007
dc.identifier.doihttp://dx.doi.org/10.25646/1263
local.edoc.container-titleInternational Journal of Medical Microbiology
local.edoc.container-textNübel, U., Strommenger, B., Layer, F., Witte, W. From types to trees: Reconstructing the spatial spread of Staphylococcus aureus based on DNA variation (2011) International Journal of Medical Microbiology, 301 (8), pp. 614-618.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.sciencedirect.com/science/article/pii/S1438422111000932
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume301
local.edoc.container-issue8
local.edoc.container-year2011

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