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2011-01-01Zeitschriftenartikel DOI: 10.4161/hv.7.0.14556
Vaccines for Leishmaniasis: From proteome to vaccine candidates
dc.contributor.authorSchroeder, Juliane
dc.contributor.authorAebischer, Toni
dc.date.accessioned2018-05-07T16:05:58Z
dc.date.available2018-05-07T16:05:58Z
dc.date.created2012-11-20
dc.date.issued2011-01-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/recDqy7GTmXSo/PDF/23UH1hwZnzD4s.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1363
dc.description.abstractLeishmania spp. cause a wide spectrum of tropical diseases which are threatening an estimated 350 million people around the globe. While in most cases non-fatal, the disease is associated with high morbidity, social stigmata and poverty. However, the most severe form visceral leishmaniasis can be fatal if left untreated. Chemotherapeutics are available but show high toxicity, costs and are prone to resistance development due to prolonged treatment periods. Healing is associated with a life-long resistance to re-infection and this argues for the feasibility of vaccination. However, despite much effort, no such vaccine has become available yet. Here, the status of vaccine development in this field is briefly summarized before the focus is set on the promise of reverse vaccinology for anti-Leishmania vaccine development in the post-genomic era. We report on our own experience with this approach using an instructive example of successful candidate vaccine antigen identification.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectAnimalseng
dc.subjectHumanseng
dc.subjectAntigens Protozoan/immunologyeng
dc.subjectLeishmaniasis Vaccines/immunologyeng
dc.subjectLeishmania/chemistryeng
dc.subjectBiomedical Research/trendseng
dc.subjectLeishmania/immunologyeng
dc.subjectLeishmaniasis/immunology*eng
dc.subjectLeishmaniasis/prevention & controleng
dc.subjectProteome/analysiseng
dc.subject.ddc610 Medizin
dc.titleVaccines for Leishmaniasis: From proteome to vaccine candidates
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10028516
dc.identifier.doi10.4161/hv.7.0.14556
dc.identifier.doihttp://dx.doi.org/10.25646/1288
local.edoc.container-titleHuman Vaccines
local.edoc.container-textJuliane Schroeder, Toni Aebischer. Vaccines for leishmaniasis: From proteome to vaccine candidates. (2011) Human Vaccines, 7 (Suppl.), pp. 10-15.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.landesbioscience.com/journals/vaccines/article/14556/
local.edoc.container-publisher-nameLandes Bioscience
local.edoc.container-volume7
local.edoc.container-issueSupplement
local.edoc.container-year2011

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