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2012-12-11Zeitschriftenartikel DOI: 10.1371/journal.pone.0051653
Comparison of Shedding Characteristics of Seasonal Influenza Virus (Sub)Types and Influenza A(H1N1)pdm09; Germany, 2007–2011
dc.contributor.authorSüß, Thorsten
dc.contributor.authorRemschmidt, Cornelius
dc.contributor.authorSchink, Susanne
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorHeider, Alla
dc.contributor.authorMilde, Jeanette
dc.contributor.authorNitsche, Andreas
dc.contributor.authorSchroeder, Kati
dc.contributor.authorDöllinger, Jörg
dc.contributor.authorBraun, Christian
dc.contributor.authorHaas, Walter
dc.contributor.authorKrause, Gérard
dc.contributor.authorBuchholz, Udo
dc.date.accessioned2018-05-07T16:09:29Z
dc.date.available2018-05-07T16:09:29Z
dc.date.created2012-12-14
dc.date.issued2012-12-11none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re2A7nRNYW1YE/PDF/29u7WfJuBVaFs.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1382
dc.description.abstractBackground: Influenza viral shedding studies provide fundamental information for preventive strategies and modelling exercises. We conducted a prospective household study to investigate viral shedding in seasonal and pandemic influenza between 2007 and 2011 in Berlin and Munich, Germany. Methods: Study physicians recruited index patients and their household members. Serial nasal specimens were obtained from all household members over at least eight days and tested quantitatively by qRT-PCR for the influenza virus (sub)type of the index patient. A subset of samples was also tested by viral culture. Symptoms were recorded daily. Results: We recruited 122 index patients and 320 household contacts, of which 67 became secondary household cases. Among all 189 influenza cases, 12 were infected with seasonal/prepandemic influenza A(H1N1), 19 with A(H3N2), 60 with influenza B, and 98 with A(H1N1)pdm09. Nine (14%) of 65 non-vaccinated secondary cases were asymptomatic/subclinical (0 (0%) of 21 children, 9 (21%) of 44 adults; p = 0.03). Viral load among patients with influenza-like illness (ILI) peaked on illness days 1, 2 or 3 for all (sub)types and declined steadily until days 7–9. Clinical symptom scores roughly paralleled viral shedding dynamics. On the first day prior to symptom onset 30% (12/40) of specimens were positive. Viral load in 6 asymptomatic/subclinical patients was similar to that in ILI-patients. Duration of infectiousness as measured by viral culture lasted approximately until illness days 4–6. Viral load did not seem to be influenced by antiviral therapy, age or vaccination status. Conclusion: Asymptomatic/subclinical infections occur infrequently, but may be associated with substantial amounts of viral shedding. Presymptomatic shedding may arise in one third of cases, and shedding characteristics appear to be independent of (seasonal or pandemic) (sub)type, age, antiviral therapy or vaccination; however the power to find moderate differences was limited.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subject.ddc610 Medizin
dc.titleComparison of Shedding Characteristics of Seasonal Influenza Virus (Sub)Types and Influenza A(H1N1)pdm09; Germany, 2007–2011
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10028882
dc.identifier.doi10.1371/journal.pone.0051653
dc.identifier.doihttp://dx.doi.org/10.25646/1307
local.edoc.container-titlePLoS ONE
local.edoc.container-textSuess T, Remschmidt C, Schink SB, Schweiger B, Heider A, et al. (2012) Comparison of Shedding Characteristics of Seasonal Influenza Virus (Sub)Types and Influenza A(H1N1)pdm09; Germany, 2007–2011. PLoS ONE 7(12): e51653.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0051653
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume7
local.edoc.container-issue12
local.edoc.container-year2012

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