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2013-01-02Zeitschriftenartikel DOI: 10.1371/journal.pone.0052068
Power-Laws and the Use of Pluripotent Stem Cell Lines
dc.contributor.authorSchuldt, Bernhard M.
dc.contributor.authorGuhr, Anke
dc.contributor.authorLenz, Michael
dc.contributor.authorKobold, Sabine
dc.contributor.authorMacArthur, Ben D.
dc.contributor.authorSchuppert, Andreas
dc.contributor.authorLöser, Peter
dc.contributor.authorMüller, Franz-Josef
dc.date.accessioned2018-05-07T16:10:47Z
dc.date.available2018-05-07T16:10:47Z
dc.date.created2013-01-08
dc.date.issued2013-01-02none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/retUSi7u8B4tM/PDF/21C324ddTJBg.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1389
dc.description.abstractIt is widely accepted that the (now reversed) Bush administration’s decision to restrict federal funding for human embryonic stem cell (hESC) research to a few “eligible” hESC lines is responsible for the sustained preferential use of a small subset of hESC lines (principally the H1 and H9 lines) in basic and preclinical research. Yet, international hESC usage patterns, in both permissive and restrictive political environments, do not correlate with a specific type of stem cell policy. Here we conducted a descriptive analysis of hESC line usage and compared the ability of policy-driven processes and collaborative processes inherent to biomedical research to recapitulate global hESC usage patterns. We find that current global hESC usage can be modelled as a cumulative advantage process, independent of restrictive or permissive policy influence, suggesting a primarily innovation-driven (rather than policy-driven) mechanism underlying human pluripotent stem cell usage in preclinical research.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Stammzellen
dc.subject.ddc610 Medizin
dc.titlePower-Laws and the Use of Pluripotent Stem Cell Lines
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10029046
dc.identifier.doi10.1371/journal.pone.0052068
dc.identifier.doihttp://dx.doi.org/10.25646/1314
local.edoc.container-titlePLoS ONE
local.edoc.container-textSchuldt BM, Guhr A, Lenz M, Kobold S, MacArthur BD, et al. (2013) Power-Laws and the Use of Pluripotent Stem Cell Lines. PLoS ONE 8(1): e52068.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052068
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume8
local.edoc.container-issue1
local.edoc.container-year2013

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