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2013-04-22Zeitschriftenartikel DOI: 10.25646/1386
Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
dc.contributor.authorHolznagel, Edgar
dc.contributor.authorYutzy, Barbara
dc.contributor.authorSchulz-Schaeffer, Walter
dc.contributor.authorKruip, Carina
dc.contributor.authorHahmann, Uwe
dc.contributor.authorBierke, Pär
dc.contributor.authorTorres, Juan-Maria
dc.contributor.authorKim, Yong-Sun
dc.contributor.authorThomzig, Achim
dc.contributor.authorBeekes, Michael
dc.contributor.authorHunsmann, Gerhard
dc.contributor.authorLöwer, Johannes
dc.date.accessioned2018-05-07T16:24:09Z
dc.date.available2018-05-07T16:24:09Z
dc.date.created2013-04-29
dc.date.issued2013-04-22none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rejzFW0MptQ/PDF/26LuraU426jsE.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1461
dc.description.abstractRisk for human exposure to bovine spongiform encephalopathy (BSE)–inducing agent was estimated in a nonhuman primate model. To determine attack rates, incubation times, and molecular signatures, we orally exposed 18 macaques to 1 high dose of brain material from cattle with BSE. Several macaques were euthanized at regular intervals starting at 1 year postinoculation, and others were observed until clinical signs developed. Among those who received ≥5 g BSE-inducing agent, attack rates were 100% and prions could be detected in peripheral tissues from 1 year postinoculation onward. The overall median incubation time was 4.6 years (3.7–5.3). However, for 3 macaques orally exposed on multiple occasions, incubation periods were at least 7–10 years. Before clinical signs were noted, we detected a non-type 2B signature, indicating the existence of atypical prion protein during the incubation period. This finding could affect diagnosis of variant Creutzfeldt-Jakob disease in humans and might be relevant for retrospective studies of positive tonsillectomy or appendectomy specimens because time of infection is unknown.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectAnimalseng
dc.subjectHumanseng
dc.subjectAmino Acid Sequenceeng
dc.subjectMolecular Sequence Dataeng
dc.subjectSequence Alignmenteng
dc.subjectCattleeng
dc.subjectDisease Models Animaleng
dc.subjectBrain/pathologyeng
dc.subjectCreutzfeldt-Jakob Syndrome/diagnosiseng
dc.subjectCreutzfeldt-Jakob Syndrome/metabolismeng
dc.subjectCreutzfeldt-Jakob Syndrome/physiopathologyeng
dc.subjectCreutzfeldt-Jakob Syndrome/transmissioneng
dc.subjectEncephalopathy Bovine Spongiform/diagnosiseng
dc.subjectEncephalopathy Bovine Spongiform/metabolismeng
dc.subjectEncephalopathy Bovine Spongiform/physiopathologyeng
dc.subjectEncephalopathy Bovine Spongiform/transmissioneng
dc.subjectFoodborne Diseases/diagnosiseng
dc.subjectFoodborne Diseases/metabolismeng
dc.subjectFoodborne Diseases/physiopathologyeng
dc.subjectInfectious Disease Incubation Periodeng
dc.subjectMacaca fasciculariseng
dc.subjectMeat/poisoningeng
dc.subjectPrPSc Proteins/chemistryeng
dc.subjectPrPSc Proteins/geneticseng
dc.subjectPrPSc Proteins/isolation & purificationeng
dc.subject.ddc610 Medizin
dc.titleFoodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10030176
dc.identifier.doihttp://dx.doi.org/10.25646/1386
local.edoc.container-titleEmerging Infectious Diseases
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://wwwnc.cdc.gov/eid/article/19/5/12-0274_article.htm
local.edoc.container-publisher-nameCenters for Disease Control and Prevention
local.edoc.container-volume19
local.edoc.container-issue5
local.edoc.container-year2013

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