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2012-03-23Zeitschriftenartikel DOI: 10.1016/j.chemolab.2012.03.011
Spectral pre-processing for biomedical vibrational spectroscopy and microspectroscopic imaging
dc.contributor.authorLasch, Peter
dc.date.accessioned2018-05-07T16:42:18Z
dc.date.available2018-05-07T16:42:18Z
dc.date.created2013-06-10
dc.date.issued2012-03-23none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rectTcBkmn0t/PDF/27CXRvU71h6M.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1560
dc.description.abstractRecent years have seen substantial progress toward the application of infrared (IR) and Raman spectroscopy as useful analytical tools in biomedical research. Vibrational spectroscopy, and (in particular) microspectroscopy, have been successfully applied to biomedical samples ranging from intact microorganisms, eukaryotic cells, body fluids, and tissues. The progress in the field was driven not only by technical developments but also by the effective implementation of modern concepts of spectral analysis. Pre-processing has been identified as an indispensable part of spectral data analysis. It involves, among others, outlier rejection, normalization, filtering, detrending, transformation, folding and feature selection. Goals of spectral pre-processing include better interpretability of the spectra, higher robustness and improved accuracy of subsequent quantitative or classification analysis. The aim of this review article is to explore the concepts and techniques of a variety of individual pre-processing methods and to discuss the applicability of different pre-processing techniques in the context of practical applications of biomedical IR or Raman spectroscopy. It is hoped that this article not only represents a useful guideline for beginners in the field of biomedical applications of vibrational spectroscopy, but serves also as a source of reference for more experienced spectroscopists.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subjectInfrared spectroscopyeng
dc.subjectSpectral pre-processingeng
dc.subjectChemometricseng
dc.subjectBiomedical vibrational spectroscopyeng
dc.subjectRaman spectroscopyeng
dc.subjectHyperspectral imagingeng
dc.subject.ddc610 Medizin
dc.titleSpectral pre-processing for biomedical vibrational spectroscopy and microspectroscopic imaging
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10031410
dc.identifier.doi10.1016/j.chemolab.2012.03.011
dc.identifier.doihttp://dx.doi.org/10.25646/1485
local.edoc.container-titleChemometrics and Intelligent Laboratory Systems
local.edoc.container-textLasch, P. Spectral pre-processing for biomedical vibrational spectroscopy and microspectroscopic imaging (2012) Chemometrics and Intelligent Laboratory Systems, 117, pp. 100-114.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.sciencedirect.com/science/article/pii/S0169743912000561
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume117
local.edoc.container-year2012

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