Zur Kurzanzeige

2013-06-01Zeitschriftenartikel DOI: 10.25646/1539
Novel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee
dc.contributor.authorCoscolla, Mireia
dc.contributor.authorLewin, Astrid
dc.contributor.authorMetzger, Sonja
dc.contributor.authorMätz-Rennsing, Kerstin
dc.contributor.authorCalvignac-Spencer, Sébastien
dc.contributor.authorNitsche, Andreas
dc.contributor.authorDabrowski, Piotr Wojtek
dc.contributor.authorRadonić, Aleksandar
dc.contributor.authorNiemann, Stefan
dc.contributor.authorParkhill, Julian
dc.contributor.authorCouacy-Hymann, Emmanuel
dc.contributor.authorFeldman, Julia
dc.contributor.authorComas, Iñaki
dc.contributor.authorBoesch, Christophe
dc.contributor.authorGagneux, Sebastien
dc.contributor.authorLeendertz, Fabian
dc.date.accessioned2018-05-07T16:52:02Z
dc.date.available2018-05-07T16:52:02Z
dc.date.created2013-07-24
dc.date.issued2013-06-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reNRZNcV9oURQ/PDF/28oQFkWt2cWZQ.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1614
dc.description.abstractTuberculosis (TB) is caused by gram-positive bacteria known as the Mycobacterium tuberculosis complex (MTBC). MTBC include several human-associated lineages and several variants adapted to domestic and, more rarely, wild animal species. We report an M. tuberculosis strain isolated from a wild chimpanzee in Côte d’Ivoire that was shown by comparative genomic and phylogenomic analyses to belong to a new lineage of MTBC, closer to the human-associated lineage 6 (also known as M. africanum West Africa 2) than to the other classical animal-associated MTBC strains. These results show that the general view of the genetic diversity of MTBC is limited and support the possibility that other MTBC variants exist, particularly in wild mammals in Africa. Exploring this diversity is crucial to the understanding of the biology and evolutionary history of this widespread infectious disease.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectAnimalseng
dc.subjectFemaleeng
dc.subjectPhylogenyeng
dc.subjectSequence Analysis DNAeng
dc.subjectGenome Bacterialeng
dc.subjectPolymorphism Single Nucleotideeng
dc.subjectApe Diseases/microbiologyeng
dc.subjectApe Diseases/pathologyeng
dc.subjectMycobacterium tuberculosis/classificationeng
dc.subjectMycobacterium tuberculosis/geneticseng
dc.subjectMycobacterium tuberculosis/isolation & purificationeng
dc.subjectPan troglodytes/microbiologyeng
dc.subjectTuberculosis/veterinaryeng
dc.subject.ddc610 Medizin
dc.titleNovel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10032115
dc.identifier.doihttp://dx.doi.org/10.25646/1539
local.edoc.container-titleEmerging Infectious Diseases
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://wwwnc.cdc.gov/eid/article/19/6/12-1012_article.htm
local.edoc.container-publisher-nameCenters for Disease Control and Prevention
local.edoc.container-volume19
local.edoc.container-issue6
local.edoc.container-year2013

Zur Kurzanzeige