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2008-08-11Zeitschriftenartikel DOI: 10.1017/S0950268808001167
Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005–2006 outbreak on Réunion
dc.contributor.authorEconomopoulou, A.
dc.contributor.authorDominguez, M.
dc.contributor.authorHelynck, B.
dc.contributor.authorSissoko, D.
dc.contributor.authorWichmann, Ole
dc.contributor.authorQuenel, P.
dc.contributor.authorGermonneau, P.
dc.contributor.authorQuatresous, I.
dc.date.accessioned2018-05-07T16:55:32Z
dc.date.available2018-05-07T16:55:32Z
dc.date.created2013-08-01
dc.date.issued2008-08-11none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reNGjFv5yX3aI/PDF/27D6oVoctSdic.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1633
dc.description.abstractIn April 2005, an outbreak of Chikungunya fever occurred on the island of Réunion in the Indian Ocean. During winter 2005, six patients developed meningoencephalitis and acute hepatitis due to Chikungunya virus. Our objectives were to determine the incidence and mortality of atypical Chikungunya viral infections and to identify risk factors for severe disease. A hospital-based surveillance system was established to collect data on atypical Chikungunya cases. Case reports, medical records and laboratory results were reviewed and analysed. We defined an atypical case as one in which a patient with laboratory-confirmed Chikungunya virus infection developed symptoms other than fever and arthralgia. We defined a severe atypical case as one which required maintenance of at least one vital function. We recorded 610 atypical cases of Chikungunya fever: 222 were severe cases, 65 affected patients died. Five hundred and forty-six cases had underlying medical conditions (of which 226 suffered from cardiovascular, 147 from neurological and 150 from respiratory disorders). Clinical features that had never been associated with Chikungunya fever were recorded, such as bullous dermatosis, pneumonia, and diabetes mellitus. Hypertension, and underlying respiratory or cardiological conditions were independent risk factors for disease severity. The overall mortality rate was 10·6% and it increased with age. This is the first time that severe cases and deaths due to Chikungunya fever have been documented. The information presented in this article may assist clinicians in identifying the disease, selecting the treatment strategy, and anticipating the course of illness.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectoutbreakeng
dc.subjectChikungunya viruseng
dc.subjectclinical manifestationseng
dc.subjectRéunioneng
dc.subjectseverityeng
dc.subject.ddc610 Medizin
dc.titleAtypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005–2006 outbreak on Réunion
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10032319
dc.identifier.doi10.1017/S0950268808001167
dc.identifier.doihttp://dx.doi.org/10.25646/1558
local.edoc.container-titleEpidemiology and Infection
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=4388028
local.edoc.container-publisher-nameCambridge University Press
local.edoc.container-volume137
local.edoc.container-issue04
local.edoc.container-year2009

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