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2013-08-07Zeitschriftenartikel DOI: 10.1371/journal.pone.0070399
The Transmembrane Protein of the Human Endogenous Retrovirus - K (HERV-K) Modulates Cytokine Release and Gene Expression
dc.contributor.authorMorozov, Vladimir
dc.contributor.authorThi, Viet Loan Dao
dc.contributor.authorDenner, Joachim
dc.date.accessioned2018-05-07T16:57:00Z
dc.date.available2018-05-07T16:57:00Z
dc.date.created2013-08-08
dc.date.issued2013-08-07none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/revdkUHbKWIhQ/PDF/24fwAESxr7OAM.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1641
dc.description.abstractNumerous copies of endogenous retroviruses are present in the genome of mammals including man. Although most of them are defective, some, e.g., the human endogenous retroviruses HERV-K, were found to be expressed under certain physiological conditions. For instance, HERV-K is expressed in germ cell tumours and melanomas as well as in the placenta. Most exogenous retroviruses including the human immunodeficiency virus HIV-1 induce severe immunodeficiencies and there is increasing evidence that the transmembrane envelope (TM) proteins of these retroviruses may be involved. We show here that HERV-K particles released from a human teratocarcinoma cell line, a recombinant TM protein and a peptide corresponding to a highly conserved so-called immunosuppressive domain in the TM protein of HERV-K inhibit the proliferation of human immune cells, induce modulation of the expression of numerous cytokines, and modulate the expression of cellular genes as detected by a microarray analysis. The changes in cytokine release and gene expression induced by the TM protein of HERV-K are similar to those found previously induced by the TM protein of HIV-1. These data suggest that the mechanism of immunosuppression may be similar for different retroviruses and that the expression of the TM protein in tumours and in the placenta may suppress immune responses and thus prevent rejection of the tumour and the embryo.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectAnimalseng
dc.subjectHumanseng
dc.subjectAmino Acid Sequenceeng
dc.subjectMolecular Sequence Dataeng
dc.subjectMiceeng
dc.subjectPeptides/geneticseng
dc.subjectMembrane Proteins/geneticseng
dc.subjectMembrane Proteins/metabolismeng
dc.subjectLeukocytes Mononuclear/metabolismeng
dc.subjectViral Proteins/geneticseng
dc.subjectViral Proteins/chemistryeng
dc.subjectViral Proteins/metabolismeng
dc.subjectMice Inbred BALB Ceng
dc.subjectBlotting Westerneng
dc.subjectBinding Sites/geneticseng
dc.subjectCell Line Tumoreng
dc.subjectCell Proliferation/drug effectseng
dc.subjectCells Culturedeng
dc.subjectCytokines/geneticseng
dc.subjectCytokines/secretioneng
dc.subjectEndogenous Retroviruses/geneticseng
dc.subjectEndogenous Retroviruses/metabolismeng
dc.subjectHEK293 Cellseng
dc.subjectInterleukin-10/geneticseng
dc.subjectInterleukin-10/secretioneng
dc.subjectLeukocytes Mononuclear/cytologyeng
dc.subjectMembrane Proteins/chemistryeng
dc.subjectOligonucleotide Array Sequence Analysiseng
dc.subjectPeptides/pharmacologyeng
dc.subjectSpleen/cytologyeng
dc.subjectSpleen/metabolismeng
dc.subjectSwine/virologyeng
dc.subjectTranscriptome/drug effectseng
dc.subjectTranscriptome/geneticseng
dc.subjectVirion/geneticseng
dc.subjectVirion/metabolismeng
dc.subject.ddc610 Medizin
dc.titleThe Transmembrane Protein of the Human Endogenous Retrovirus - K (HERV-K) Modulates Cytokine Release and Gene Expression
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10032445
dc.identifier.doi10.1371/journal.pone.0070399
dc.identifier.doihttp://dx.doi.org/10.25646/1566
local.edoc.container-titlePLoS ONE
local.edoc.container-textMorozov VA, Dao Thi VL, Denner J (2013) The Transmembrane Protein of the Human Endogenous Retrovirus - K (HERV-K) Modulates Cytokine Release and Gene Expression. PLoS ONE 8(8): e70399.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0070399
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume8
local.edoc.container-issue8
local.edoc.container-year2013

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