Show simple item record

2013-09-20Zeitschriftenartikel DOI: 10.3389/fonc.2013.00246
HERV-K(HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease
dc.contributor.authorHohn, Oliver
dc.contributor.authorHanke, Kirsten
dc.contributor.authorBannert, Norbert
dc.date.accessioned2018-05-07T17:03:40Z
dc.date.available2018-05-07T17:03:40Z
dc.date.created2013-10-14
dc.date.issued2013-09-20none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reBi9oS5gg7E/PDF/206YYBAY3Nw.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1677
dc.description.abstractRetroviruses that have the ability to infect germ line cells can become an integral and inherited part of the host genome. About 8% of the human chromosomal DNA consists of sequences derived from infections by retroviruses that presumably circulated 2–40 millions of years ago, and some elements are actually much older. Post-insertional recombinations, deletions, and mutations have rendered all known human endogenous retroviruses (HERVs) non-infectious. However some, particularly the most recently acquired proviruses of the HERV-K(HML-2) family, can expresses viral proteins and produce viral particles. In this review we will first discuss the major aspects of the endogenization process and peculiarities of the different HERV-K families. We will then focus on the genes and proteins encoded by HERV-K(HML-2) as well as inactivation of these proviruses by postinsertional mutations and their inhibition by antiretroviral factors. After describing the evolutionary interplay between host and endogenous retrovirus we will delve deeper into the currently limited understanding of HERV-K and its possible association with disease, particularly tumorigenesis.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subjecthuman endogenous retroviruseng
dc.subjectHERV-Keng
dc.subjectreplicationeng
dc.subjectReceng
dc.subjectcancereng
dc.subject.ddc610 Medizin
dc.titleHERV-K(HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10033015
dc.identifier.doi10.3389/fonc.2013.00246
dc.identifier.doihttp://dx.doi.org/10.25646/1602
local.edoc.container-titleFrontiers in Oncology
local.edoc.container-textHohn O, Hanke K and Bannert N (2013) HERV-K(HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease. Front. Oncol. 3:246.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.frontiersin.org/Molecular_and_Cellular_Oncology/10.3389/fonc.2013.00246/abstract
local.edoc.container-publisher-nameFrontiers Media
local.edoc.container-volume3
local.edoc.container-year2013

Show simple item record