Show simple item record

2013-12-12Zeitschriftenartikel DOI: 10.25646/1714
Transmission and molecular characterisation of wild measles virus in Romania, 2008 to 2012
dc.contributor.authorNecula, Gheorghe
dc.contributor.authorLazar, M.
dc.contributor.authorStanescu, A.
dc.contributor.authorPistol, A.
dc.contributor.authorSantibanez, Sabine
dc.contributor.authorMankertz, Annette
dc.contributor.authorLupulescu, E.
dc.date.accessioned2018-05-07T17:23:59Z
dc.date.available2018-05-07T17:23:59Z
dc.date.created2014-01-20
dc.date.issued2013-12-12none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re1TtphCKYyk/PDF/21FLJIKO7HR0s.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1789
dc.description.abstractMolecular characterisation of measles virus is a powerful tool for tracing transmission. Genotyping may prove the absence of endemic circulation of measles virus, i.e. transmission for more than 12 months, which is one of the criteria for verifying elimination of the disease. We have genetically characterised measles viruses detected in Romania from 2008 to 2012, focusing on the recent outbreaks from 2010 to 2012 that affected mainly groups with limited access to healthcare and schools. The findings emphasise the importance of genotyping during the different phases of an outbreak. A total of 8,170 cases were notified, and 5,093 (62%) of the 7,559 possible cases were serologically confirmed. RT-PCR was performed for 104 samples: from the 101 positive samples obtained from sporadic measles cases or clusters from different counties, 73 were genotyped. Sporadic measles cases associated with D4 and D5 viruses were observed from 2008 to 2009. Genotype D4-Manchester was predominant in 2011 and 2012. In addition, the related variant D4-Maramures and MVs/Limoges.FRA/17.10[D4] and a few D4-Hamburg strains were detected. The detection of several distinct MV-D4 genotypes suggests multiple virus importations to Romania. The outbreak associated with D4 genotype is the second largest outbreak in Romania in less than 10 years.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectSequence Analysiseng
dc.subjectMolecular Epidemiology/methodseng
dc.subjectGenotypeeng
dc.subjectPhylogenyeng
dc.subjectDisease Notification/statistics & numerical dataeng
dc.subjectPopulation Surveillanceeng
dc.subjectChild Preschooleng
dc.subjectInfanteng
dc.subjectChildeng
dc.subjectDisease Outbreakseng
dc.subjectAntibodies Viral/analysiseng
dc.subjectAntibodies Viral/geneticseng
dc.subjectInfant Newborneng
dc.subjectMeasles/epidemiologyeng
dc.subjectMeasles/geneticseng
dc.subjectMeasles/transmissioneng
dc.subjectMeasles virus/geneticseng
dc.subjectMeasles virus/immunologyeng
dc.subjectReverse Transcriptase Polymerase Chain Reactioneng
dc.subjectRomania/epidemiologyeng
dc.subject.ddc610 Medizin
dc.titleTransmission and molecular characterisation of wild measles virus in Romania, 2008 to 2012
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10034552
dc.identifier.doihttp://dx.doi.org/10.25646/1714
local.edoc.container-titleEuroSurveillance
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20658
local.edoc.container-publisher-nameECDC
local.edoc.container-volume18
local.edoc.container-issue50
local.edoc.container-year2013

Show simple item record