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2013-07-01Zeitschriftenartikel DOI: 10.1038/bmt.2013.94
Risk factors and containment of respiratory syncytial virus outbreak in a hematology and transplant unit
dc.contributor.authorLehners, N.
dc.contributor.authorSchnitzler, P.
dc.contributor.authorGeis, S.
dc.contributor.authorPuthenparambil, J.
dc.contributor.authorBenz, M. A.
dc.contributor.authorAlber, B.
dc.contributor.authorLuft, T.
dc.contributor.authorDreger, P.
dc.contributor.authorEisenbach, C.
dc.contributor.authorKunz, C.
dc.contributor.authorBenner, A.
dc.contributor.authorBuchholz, Udo
dc.contributor.authorAichinger, E.
dc.contributor.authorFrank, U.
dc.contributor.authorHeeg, K.
dc.contributor.authorHo, A. D.
dc.contributor.authorEgerer, G.
dc.date.accessioned2018-05-07T17:26:23Z
dc.date.available2018-05-07T17:26:23Z
dc.date.created2014-01-30
dc.date.issued2013-07-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reDaLKd1yuvbg/PDF/26kHxJQ1qOzA.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1802
dc.description.abstractRespiratory syncytial virus (RSV) usually causes self-limiting upper respiratory tract infections, but can be associated with severe lower respiratory tract infection disease (LRTID) in infants and in patients with hematologic malignancies. We have analyzed the risk factors and the measures for containment within an outbreak of nosocomial RSV infections in a hematology and SCT unit. A total of 56 patients were affected (53 RSV-A and 3 RSV-B) including 32 transplant patients (16 allogeneic and 16 autologous). Forty (71%) of the 56 patients suffered from LRTID and 14 (35%) of the patients with LRTID subsequently died. However, because of concomitant infections with fungal and bacterial pathogens, the impact of RSV on the fatal outcome was difficult to assess. Multivariate analysis showed that low levels of IgG were significantly associated with fatal outcome (P=0.007), treatment with oral ribavirin represented a protective factor (P=0.02). An extremely protracted viral shedding was observed in this cohort of patients (median=30.5 days, range: 1–162 days), especially pronounced in patients after allogeneic transplantation (P=0.002). Implementation of rigorous isolation and barrier measures, although challenged by long-term viral carriers, was effective in containment of the outbreak.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectrisk factorseng
dc.subjectallogeneic transplantationeng
dc.subjectRSVeng
dc.subjectoutbreakeng
dc.subjectcontainmenteng
dc.subject.ddc610 Medizin
dc.titleRisk factors and containment of respiratory syncytial virus outbreak in a hematology and transplant unit
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10034732
dc.identifier.doi10.1038/bmt.2013.94
dc.identifier.doihttp://dx.doi.org/10.25646/1727
local.edoc.container-titleBone Marrow Transplantation
local.edoc.container-textLehners, N. et al. Risk factors and containment of respiratory syncytial virus outbreak in a hematology and transplant unit. Bone Marrow Transplant 48, 1548-1553, (2013).
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.nature.com/bmt/journal/v48/n12/full/bmt201394a.html
local.edoc.container-publisher-nameNature Publishing Group
local.edoc.container-volume48
local.edoc.container-year2013

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