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2014-02-04Zeitschriftenartikel DOI: 10.1371/journal.pone.0088083
Phylogenetic Analysis of Staphylococcus aureus CC398 Reveals a Sub-Lineage Epidemiologically Associated with Infections in Horses
dc.contributor.authorAbdelbary, Mohamed M. H.
dc.contributor.authorWittenberg, Anne
dc.contributor.authorCuny, Christiane
dc.contributor.authorLayer, Franziska
dc.contributor.authorKurt, Kevin
dc.contributor.authorWieler, Lothar H.
dc.contributor.authorWalther, Birgit
dc.contributor.authorSkov, Robert
dc.contributor.authorLarsen, Jesper
dc.contributor.authorHasman, Henrik
dc.contributor.authorFitzgerald, J. Ross
dc.contributor.authorSmith, Tara C.
dc.contributor.authorWagenaar, J. A.
dc.contributor.authorPantosti, Annalisa
dc.contributor.authorHallin, Marie
dc.contributor.authorStruelens, Marc J.
dc.contributor.authorEdwards, Giles
dc.contributor.authorBöse, R.
dc.contributor.authorNübel, Ulrich
dc.contributor.authorWitte, Wolfgang
dc.date.accessioned2018-05-07T17:29:41Z
dc.date.available2018-05-07T17:29:41Z
dc.date.created2014-02-17
dc.date.issued2014-02-04none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reWjW6AUtsHGM/PDF/244pvnHTHLwHk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1820
dc.description.abstractIn the early 2000s, a particular MRSA clonal complex (CC398) was found mainly in pigs and pig farmers in Europe. Since then, CC398 has been detected among a wide variety of animal species worldwide. We investigated the population structure of CC398 through mutation discovery at 97 genetic housekeeping loci, which are distributed along the CC398 chromosome within 195 CC398 isolates, collected from various countries and host species, including humans. Most of the isolates in this collection were received from collaborating microbiologists, who had preserved them over years. We discovered 96 bi-allelic polymorphisms, and phylogenetic analyses revealed that an epidemic sub-clone within CC398 (dubbed ‘clade (C)’) has spread within and between equine hospitals, where it causes nosocomial infections in horses and colonises the personnel. While clade (C) was strongly associated with S. aureus from horses in veterinary-care settings (p = 2×10−7), it remained extremely rare among S. aureus isolates from human infections.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectAnimalseng
dc.subjectHumanseng
dc.subjectPhylogenyeng
dc.subjectStaphylococcal Infections/microbiologyeng
dc.subjectStaphylococcus aureus/geneticseng
dc.subjectStaphylococcal Infections/epidemiologyeng
dc.subjectGenetic Loci/geneticseng
dc.subjectHorses/microbiologyeng
dc.subjectHorse Diseases/epidemiologyeng
dc.subjectHorse Diseases/geneticseng
dc.subjectHorse Diseases/microbiologyeng
dc.subjectHospitals Animaleng
dc.subjectPolymorphism Genetic/geneticseng
dc.subjectStaphylococcal Infections/geneticseng
dc.subject.ddc610 Medizin
dc.titlePhylogenetic Analysis of Staphylococcus aureus CC398 Reveals a Sub-Lineage Epidemiologically Associated with Infections in Horses
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10035073
dc.identifier.doi10.1371/journal.pone.0088083
dc.identifier.doihttp://dx.doi.org/10.25646/1745
local.edoc.container-titlePLoS ONE
local.edoc.container-textAbdelbary MMH, Wittenberg A, Cuny C, Layer F, Kurt K, et al. (2014) Phylogenetic Analysis of Staphylococcus aureus CC398 Reveals a Sub-Lineage Epidemiologically Associated with Infections in Horses. PLoS ONE 9(2): e88083.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088083
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume9
local.edoc.container-issue2
local.edoc.container-year2014

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