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2013-03-26Zeitschriftenartikel DOI: 10.1016/j.meegid.2013.03.013
Staphylococcus aureus toxins – Their functions and genetics
dc.contributor.authorGrumann, Dorothee
dc.contributor.authorNübel, Ulrich
dc.contributor.authorBröker, Barbara M.
dc.date.accessioned2018-05-07T17:37:41Z
dc.date.available2018-05-07T17:37:41Z
dc.date.created2014-04-16
dc.date.issued2013-03-26none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reLNV7Y9x39tQ/PDF/24fXtqiE38LjQ.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1863
dc.description.abstractThe outcome of encounters between Staphylococcus (S.) aureus and its human host ranges from life-threatening infection through allergic reactions to symptom-free colonization. The pan-genome of this bacterial species encodes numerous toxins, known or strongly suspected to cause specific diseases or symptoms. Three toxin families are in the focus of this review, namely (i) pore-forming toxins, (ii) exfoliative toxins and (iii) superantigens. The majority of toxin-encoding genes are located on mobile genetic elements (MGEs), resulting in a pronounced heterogeneity in the endowment with toxin genes of individual S. aureus strains. Recent population genomic analysis have provided a framework for an improved understanding of the temporal and spatial scales of the motility of MGEs and their associated toxin genes. The distribution of toxin genes among clonal lineages within the species S. aureus is not random, and phylogenetic (sub-)lineages within clonal complexes feature characteristic toxin signatures. When studying pathogenesis, this lineage association, which is caused by the clonal nature of S. aureus makes it difficult to discriminate effects of specific toxins from contributions of the genetic background and/or other associated genetic factors.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectEpidemiologyeng
dc.subjectS. aureuseng
dc.subjectPore-forming toxinseng
dc.subjectExfoliative toxinseng
dc.subjectSuperantigenseng
dc.subjectEvolutioneng
dc.subject.ddc610 Medizin
dc.titleStaphylococcus aureus toxins – Their functions and genetics
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10036182
dc.identifier.doi10.1016/j.meegid.2013.03.013
dc.identifier.doihttp://dx.doi.org/10.25646/1788
local.edoc.container-titleInfection, Genetics and Evolution
local.edoc.container-textGrumann, D., Nübel, U., Bröker, B.M. Staphylococcus aureus toxins - Their functions and genetics (2014) Infection, Genetics and Evolution, 21, pp. 583-592.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.sciencedirect.com/science/article/pii/S1567134813000865
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume21
local.edoc.container-issue1
local.edoc.container-year2014

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