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2014-05-08Zeitschriftenartikel DOI: 10.1371/journal.ppat.1004110
Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza
dc.contributor.authorLiu, Francesca Diane M.
dc.contributor.authorKenngott, Elisabeth E.
dc.contributor.authorSchröter, Micha F.
dc.contributor.authorKühl, Anja
dc.contributor.authorJennrich, Silke
dc.contributor.authorWatzlawick, Ralf
dc.contributor.authorHoffmann, Ute
dc.contributor.authorWolff, Thorsten
dc.contributor.authorNorley, Stephen
dc.contributor.authorScheffold, Alexander
dc.contributor.authorStumhofer, Jason S.
dc.contributor.authorSaris, Christiaan J. M.
dc.contributor.authorSchwab, Jan M.
dc.contributor.authorHunter, Christopher A.
dc.contributor.authorDebes, Gudrun F.
dc.contributor.authorHamann, Alf
dc.date.accessioned2018-05-07T17:41:13Z
dc.date.available2018-05-07T17:41:13Z
dc.date.created2014-05-27
dc.date.issued2014-05-08none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rerJraduncFMY/PDF/20G7E8oX904nA.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1882
dc.description.abstractInfection with influenza virus can result in massive pulmonary infiltration and potentially fatal immunopathology. Understanding the endogenous mechanisms that control immunopathology could provide a key to novel adjunct therapies for this disease. Here we show that the cytokine IL-27 plays a crucial role in protection from exaggerated inflammation during influenza virus infection. Using Il-27ra−/− mice, IL-27 was found to limit immunopathology, neutrophil accumulation, and dampened TH1 or TH17 responses via IL-10–dependent and -independent pathways. Accordingly, the absence of IL-27 signals resulted in a more severe disease course and in diminished survival without impacting viral loads. Consistent with the delayed expression of endogenous Il-27p28 during influenza, systemic treatment with recombinant IL-27 starting at the peak of virus load resulted in a major amelioration of lung pathology, strongly reduced leukocyte infiltration and improved survival without affecting viral clearance. In contrast, early application of IL-27 impaired virus clearance and worsened disease. These findings demonstrate the importance of IL-27 for the physiological control of immunopathology and the potential value of well-timed IL-27 application to treat life-threatening inflammation during lung infection.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectAnimalsger
dc.subjectCells Culturedger
dc.subjectChick Embryoger
dc.subjectCytoprotection/geneticsger
dc.subjectCytoprotection/immunologyger
dc.subjectImmunity Innate/geneticsger
dc.subjectInfluenza A virus/immunologyger
dc.subjectInterleukins/physiologyger
dc.subjectMiceger
dc.subjectMice Inbred BALB Cger
dc.subjectMice Inbred C57BLger
dc.subjectMice Knockoutger
dc.subjectOrthomyxoviridae Infections/geneticsger
dc.subjectOrthomyxoviridae Infections/immunologyger
dc.subjectReceptors Cytokine/geneticsger
dc.subjectRespiratory Tract Infections/immunologyger
dc.subjectRespiratory Tract Infections/pathologyger
dc.subjectRespiratory Tract Infections/virologyger
dc.subjectTime Factorsger
dc.subject.ddc610 Medizin
dc.titleTimed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10036702
dc.identifier.doi10.1371/journal.ppat.1004110
dc.identifier.doihttp://dx.doi.org/10.25646/1807
local.edoc.container-titlePLoS Pathogens
local.edoc.container-textLiu FDM, Kenngott EE, Schröter MF, Kühl A, Jennrich S, et al. (2014) Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza. PLoS Pathog 10(5): e1004110.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1004110
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume10
local.edoc.container-issue5
local.edoc.container-year2014

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