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2014-05-21Zeitschriftenartikel DOI: 10.1038/mi.2014.40
Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells
dc.contributor.authorCerovic, V.
dc.contributor.authorHouston, S. A.
dc.contributor.authorWestlund, J.
dc.contributor.authorUtriainen, L.
dc.contributor.authorDavison, E. S.
dc.contributor.authorScott, C. L.
dc.contributor.authorBain, C. C.
dc.contributor.authorJoeris, T.
dc.contributor.authorAgace, W. W.
dc.contributor.authorKroczek, Richard
dc.contributor.authorMowat, A. M.
dc.contributor.authorYrlid, U.
dc.contributor.authorMilling, S. W. F.
dc.date.accessioned2018-05-07T17:45:38Z
dc.date.available2018-05-07T17:45:38Z
dc.date.created2014-06-30
dc.date.issued2014-05-21none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reArZVt4DqSsA/PDF/22rOgec19Iutg.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1906
dc.description.abstractCross-presentation of cellular antigens is crucial for priming CD8+ T cells, and generating immunity to intracellular pathogens—particularly viruses. It is unclear which intestinal phagocytes perform this function in vivo. To address this, we examined dendritic cells (DCs) from the intestinal lymph of IFABP-tOVA 232-4 mice, which express ovalbumin in small intestinal epithelial cells (IECs). Among lymph DCs (LDCs) only CD103+ CD11b− CD8α+ DCs cross-present IEC-derived ovalbumin to CD8+ OT-I T cells. Similarly, in the mesenteric lymph nodes (MLNs), cross-presentation of IEC–ovalbumin was limited to the CD11c+ MHCIIhi CD8α+ migratory DCs, but absent from all other subsets, including the resident CD8αhi DCs. Crucially, delivery of purified CD8α+ LDCs, but not other LDC subsets, into the MLN subcapsular lymphatic sinus induced proliferation of ovalbumin-specific, gut-tropic CD8+ T cells in vivo. Finally, in 232-4 mice treated with R848, CD8α+ LDCs were uniquely able to cross-prime interferon γ-producing CD8+ T cells and drive their migration to the intestine. Our results clearly demonstrate that migrating CD8α+ intestinal DCs are indispensable for cross-presentation of cellular antigens and, in conditions of inflammation, for the initial differentiation of effector CD8+ T cells. They may therefore represent an important target for the development of antiviral vaccinations.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAnimalseng
dc.subjectMiceeng
dc.subjectMice Inbred C57BLeng
dc.subjectMice Knockouteng
dc.subjectMice Transgeniceng
dc.subjectDendritic Cells/immunologyeng
dc.subjectOvalbumin/immunologyeng
dc.subjectCell Proliferation/drug effectseng
dc.subjectCells Culturedeng
dc.subjectAntigens/immunologyeng
dc.subjectAntigens CD8/metabolismeng
dc.subjectCD8-Positive T-Lymphocytes/immunologyeng
dc.subjectCell Movement/drug effectseng
dc.subjectCell Movement/geneticseng
dc.subjectCross-Priming/drug effectseng
dc.subjectCross-Priming/geneticseng
dc.subjectImidazoles/administration & dosageeng
dc.subjectImidazoles/pharmacologyeng
dc.subjectInterferon-gamma/metabolismeng
dc.subjectIntestinal Mucosa/immunologyeng
dc.subjectLymph/immunologyeng
dc.subjectLymphocyte Activation/drug effectseng
dc.subjectLymphocyte Activation/geneticseng
dc.subjectMembrane Glycoproteins/agonistseng
dc.subjectOvalbumin/geneticseng
dc.subjectOvalbumin/metabolismeng
dc.subjectToll-Like Receptor 7/agonistseng
dc.subject.ddc610 Medizin
dc.titleLymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10036784
dc.identifier.doi10.1038/mi.2014.40
dc.identifier.doihttp://dx.doi.org/10.25646/1831
local.edoc.container-titleMucosal Immunology
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.nature.com/mi/journal/vaop/ncurrent/full/mi201440a.html
local.edoc.container-publisher-nameNature Publishing Group
local.edoc.container-volume8
local.edoc.container-issue1
local.edoc.container-year2015

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