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2014-05-01Zeitschriftenartikel DOI: 10.1007/s00125-014-3247-3
Breast-feeding and maternal risk of type 2 diabetes: a prospective study and meta-analysis
dc.contributor.authorJäger, Susanne
dc.contributor.authorJacobs, Simone
dc.contributor.authorKröger, Janine
dc.contributor.authorFritsche, Andreas
dc.contributor.authorSchienkiewitz, Anja
dc.contributor.authorRubin, Diana
dc.contributor.authorBoeing, Heiner
dc.contributor.authorSchulze, Matthias B.
dc.date.accessioned2018-05-07T17:46:12Z
dc.date.available2018-05-07T17:46:12Z
dc.date.created2014-07-01
dc.date.issued2014-05-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reSJjHNLcOHw/PDF/24NG3xEhsMOk6.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1909
dc.description.abstractAims/hypothesis: We aimed to examine the association between breast-feeding and maternal risk of type 2 diabetes and to investigate whether this association is mediated by anthropometric and biochemical factors. Methods: A case–cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study between 1994 and 2005 including 1,262 childbearing women (1,059 in a random sub-cohort and 203 incident cases) mainly aged between 35 and 64 years at baseline was applied. Self-reported lifetime duration of breast-feeding was assessed by questionnaire. Blood samples were used for biomarker measurement (HDL-cholesterol, triacylglycerols, C-reactive protein, fetuin-A, γ-glutamyltransferase, adiponectin). A systematic literature search and meta-analysis was conducted of prospective cohort studies investigating breast-feeding and risk of type 2 diabetes. Results: The HR for each additional 6 months of breast-feeding was 0.73 (95% CI 0.56, 0.94) in EPIC-Potsdam. Meta-analysis of three previous prospective studies and the current study revealed an inverse association between breast-feeding duration and risk of diabetes (pooled HR for lifetime breast-feeding duration of 6–11 months compared with no breast-feeding 0.89; 95% CI 0.82, 0.97). Adjustment for BMI and waist circumference attenuated the association (HR per six additional months in EPIC-Potsdam 0.80; 95% CI 0.61, 1.04). Further controlling for potentially mediating biomarkers largely explained this association (HR 0.89; 95% CI 0.68, 1.16). Conclusions/interpretation: Longer duration of breast-feeding may be related to a lower risk of diabetes. This potentially protective effect seems to be reflected by a more favourable metabolic profile; however, the role of body weight as a mediator or confounder remains uncertain.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
dc.subjectEpidemiologyeng
dc.subjectAdiponectineng
dc.subjectBreast-feedingeng
dc.subjectHDL-cholesteroleng
dc.subjectMeta-analysiseng
dc.subjectTriacylglycerolseng
dc.subjectType 2 diabeteseng
dc.subjectWeighteng
dc.subjectWomen’s healtheng
dc.subject.ddc610 Medizin
dc.titleBreast-feeding and maternal risk of type 2 diabetes: a prospective study and meta-analysis
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10036810
dc.identifier.doi10.1007/s00125-014-3247-3
dc.identifier.doihttp://dx.doi.org/10.25646/1834
local.edoc.container-titleDiabetologia
local.edoc.container-textThis article is published with open access at Springerlink.com
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://link.springer.com/article/10.1007%2Fs00125-014-3247-3
local.edoc.container-publisher-nameSpringer
local.edoc.container-volume57
local.edoc.container-issue7
local.edoc.container-year2014

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