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2014-07-08Zeitschriftenartikel DOI: 10.1371/journal.pone.0101738
Trends and Predictors of Transmitted Drug Resistance (TDR) and Clusters with TDR in a Local Belgian HIV-1 Epidemic
dc.contributor.authorPineda-Peña, Andrea-Clemencia
dc.contributor.authorSchrooten, Yoeri
dc.contributor.authorVinken, Lore
dc.contributor.authorFerreira, Fossie
dc.contributor.authorLi, Guangdi
dc.contributor.authorTrovão, Nídia Sequeira
dc.contributor.authorKhouri, Ricardo
dc.contributor.authorDerdelinckx, Inge
dc.contributor.authorMunter, Paul De
dc.contributor.authorKücherer, Claudia
dc.contributor.authorKostrikis, Leondios G.
dc.contributor.authorNielsen, Claus
dc.contributor.authorLittsola, Kirsi
dc.contributor.authorWensing, Annemarie
dc.contributor.authorStanojevic, Maja
dc.contributor.authorParedes, Roger
dc.contributor.authorBalotta, Claudia
dc.contributor.authorAlbert, Jan
dc.contributor.authorBoucher, Charles
dc.contributor.authorGomez-Lopez, Arley
dc.contributor.authorWijngaerden, Eric van
dc.contributor.authorRanst, Marc van
dc.contributor.authorVercauteren, Jurgen
dc.contributor.authorVandamme, Anne-Mieke
dc.contributor.authorLaethem, Kristel van
dc.date.accessioned2018-05-07T17:48:58Z
dc.date.available2018-05-07T17:48:58Z
dc.date.created2014-08-07
dc.date.issued2014-07-08none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reKK9ywIyYlL/PDF/28Wr6usT6lPk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1924
dc.description.abstractWe aimed to study epidemic trends and predictors for transmitted drug resistance (TDR) in our region, its clinical impact and its association with transmission clusters. We included 778 patients from the AIDS Reference Center in Leuven (Belgium) diagnosed from 1998 to 2012. Resistance testing was performed using population-based sequencing and TDR was estimated using the WHO-2009 surveillance list. Phylogenetic analysis was performed using maximum likelihood and Bayesian techniques. The cohort was predominantly Belgian (58.4%), men who have sex with men (MSM) (42.8%), and chronically infected (86.5%). The overall TDR prevalence was 9.6% (95% confidence interval (CI): 7.7–11.9), 6.5% (CI: 5.0–8.5) for nucleoside reverse transcriptase inhibitors (NRTI), 2.2% (CI: 1.4–3.5) for non-NRTI (NNRTI), and 2.2% (CI: 1.4–3.5) for protease inhibitors. A significant parabolic trend of NNRTI-TDR was found (p = 0.019). Factors significantly associated with TDR in univariate analysis were male gender, Belgian origin, MSM, recent infection, transmission clusters and subtype B, while multivariate and Bayesian network analysis singled out subtype B as the most predictive factor of TDR. Subtype B was related with transmission clusters with TDR that included 42.6% of the TDR patients. Thanks to resistance testing, 83% of the patients with TDR who started therapy had undetectable viral load whereas half of the patients would likely have received a suboptimal therapy without this test. In conclusion, TDR remained stable and a NNRTI up-and-down trend was observed. While the presence of clusters with TDR is worrying, we could not identify an independent, non-sequence based predictor for TDR or transmission clusters with TDR that could help with guidelines or public health measures.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectAdulteng
dc.subjectAgedeng
dc.subjectMiddle Agedeng
dc.subjectRisk Factorseng
dc.subjectYoung Adulteng
dc.subjectAnti-HIV Agents/therapeutic useeng
dc.subjectHIV Infections/epidemiologyeng
dc.subjectHIV Infections/virologyeng
dc.subjectPrevalenceeng
dc.subjectGenotypeeng
dc.subjectCluster Analysiseng
dc.subjectHIV-1/geneticseng
dc.subjectRetrospective Studieseng
dc.subjectHIV Infections/drug therapyeng
dc.subjectHIV-1/drug effectseng
dc.subjectPublic Health Surveillanceeng
dc.subjectMicrobial Sensitivity Testseng
dc.subjectHIV Infections/transmissioneng
dc.subjectDrug Resistance Viral/geneticseng
dc.subjectAnti-HIV Agents/pharmacologyeng
dc.subjectBelgium/epidemiologyeng
dc.subjectPregnancyeng
dc.subject.ddc610 Medizin
dc.titleTrends and Predictors of Transmitted Drug Resistance (TDR) and Clusters with TDR in a Local Belgian HIV-1 Epidemic
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10037101
dc.identifier.doi10.1371/journal.pone.0101738
dc.identifier.doihttp://dx.doi.org/10.25646/1849
local.edoc.container-titlePLoS ONE
local.edoc.container-textPineda-Peña A-C, Schrooten Y, Vinken L, Ferreira F, Li G, et al. (2014) Trends and Predictors of Transmitted Drug Resistance (TDR) and Clusters with TDR in a Local Belgian HIV-1 Epidemic. PLoS ONE 9(7): e101738.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0101738
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume9
local.edoc.container-issue7
local.edoc.container-year2014

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