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2014-10-20Zeitschriftenartikel DOI: 10.1186/1475-2875-13-413
Malaria parasite detection increases during pregnancy in wild chimpanzees
dc.contributor.authorNys, Hélène M. de
dc.contributor.authorCalvignac-Spencer, Sébastien
dc.contributor.authorBoesch, Christophe
dc.contributor.authorDorny, Pierre
dc.contributor.authorWittig, Roman M.
dc.contributor.authorMundry, Roger
dc.contributor.authorLeendertz, Fabian
dc.date.accessioned2018-05-07T17:58:21Z
dc.date.available2018-05-07T17:58:21Z
dc.date.created2014-10-28
dc.date.issued2014-10-20none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/revODjj5Y7EIY/PDF/21xI06b4nXq92.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1974
dc.description.abstractBackground: The diversity of malaria parasites (Plasmodium sp.) infecting chimpanzees (Pan troglodytes) and their close relatedness with those infecting humans is well documented. However, their biology is still largely unexplored and there is a need for baseline epidemiological data. Here, the effect of pregnancy, a well-known risk factor for malaria in humans, on the susceptibility of female chimpanzees to malaria infection was investigated. Methods: A series of 384 faecal samples collected during 40 pregnancies and 36 post-pregnancies from three habituated groups of wild chimpanzees in the Taï National Park, Côte d’Ivoire, were tested. Samples were tested for malaria parasites by polymerase chain reaction (PCR) and sequencing. Data were analysed using a generalized linear mixed model. Results: Probability of malaria parasite detection significantly increased towards the end of pregnancy and decreased with the age of the mother. Conclusions: This study provides evidence that susceptibility to malaria parasite infection increases during pregnancy, and, as shown before, in younger individuals, which points towards similar dynamics of malaria parasite infection in human and chimpanzee populations and raises questions about the effects of such infections on pregnancy outcome and offspring morbidity/mortality.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectPregnancyeng
dc.subjectEpidemiologyeng
dc.subjectMalariaeng
dc.subjectChimpanzeeeng
dc.subjectPlasmodiumeng
dc.subjectGreat apeeng
dc.subject.ddc610 Medizin
dc.titleMalaria parasite detection increases during pregnancy in wild chimpanzees
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10037855
dc.identifier.doi10.1186/1475-2875-13-413
dc.identifier.doihttp://dx.doi.org/10.25646/1899
local.edoc.container-titleMalaria Journal
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.malariajournal.com/content/13/1/413
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume13
local.edoc.container-issue413
local.edoc.container-year2014

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