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2015-02-27Zeitschriftenartikel DOI: 10.1186/s13756-015-0047-6
Cross-border comparison of the Dutch and German guidelines on multidrug-resistant Gram-negative microorganisms
dc.contributor.authorMüller, Jan
dc.contributor.authorVoss, Andreas
dc.contributor.authorKöck, Robin
dc.contributor.authorSinha, Bhanu
dc.contributor.authorRossen, John W.
dc.contributor.authorKaase, Martin
dc.contributor.authorMielke, Martin
dc.contributor.authorDaniels-Haardt, Inka
dc.contributor.authorJurke, Annette
dc.contributor.authorHendrix, Ron
dc.contributor.authorKluytmans, Jan A.
dc.contributor.authorBergh, Marjolein F. Kluytmans-van den
dc.contributor.authorPulz, Matthias
dc.contributor.authorHerrmann, Jörg
dc.contributor.authorKern, Winfried V.
dc.contributor.authorWendt, Constanze
dc.contributor.authorFriedrich, Alex W.
dc.date.accessioned2018-05-07T18:08:02Z
dc.date.available2018-05-07T18:08:02Z
dc.date.created2015-03-11
dc.date.issued2015-02-27none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re2hIlNVrfmCw/PDF/29K2L4HrV4tQI.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2026
dc.description.abstractBackground: In all European countries, hospital-acquired infections caused by Gram-negative multidrug-resistant microorganisms (GN-MDRO) are a major health threat, as these pathogens cannot be adequately treated anymore, or the start of effective antibiotic treatment is delayed. The efforts to limit the selection and spread of GN-MDRO remains a problem in cross-border healthcare, as the national guidelines on hygiene standards applicable for patients colonized or infected with GN-MDRO in hospitals are not harmonized between European countries. Methods: In order to point out the similarities and differences in the national guidelines of Germany and The Netherlands regarding GN-MDRO, guidelines were compared and an expert workshop was organized by the INTERREG IVa project EurSafety Health-net. Results: Both guidelines divide the Gram-negative organisms into subgroups based on bacterial species and antibiotic susceptibility patterns in order to define multidrug-resistant variants of these bacteria. However, the Dutch guideline defines that GN-MDRO Enterobacteriaceae requires testing for certain mechanisms causing antibiotic resistance, whereas the German guideline makes use of a newly created classification scheme, based on phenotypic characterization. Besides diagnostic issues, the main difference between the Dutch and German guideline is the divergent evaluation of ESBL-producing Enterobacteriaceae. Special hygiene measures are required for all patients with ESBL-producing Enterobacteriaceae in The Netherlands, whereas the German guideline recommends special precautions only for those cases in which patients are colonized or infected with strains showing co-resistance to ciprofloxacin (“3MRGN”). Conclusions: The usage of consistent terminology and harmonized diagnostic procedures would improve the possibilities for infection prevention, treatment and patient safety. Prevention of severe non-treatable infections and outbreaks due to MDRO, caused by an increased population seeking medical treatment abroad together with an increased number of highly susceptible individuals demands gathering of regional data, and data comparable between the two sides of the Dutch-German border. The necessity to cooperate multidisciplinary and across borders is required to prevent a post-antibiotic era – in which common infections and minor injuries may lead to death.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectMDROeng
dc.subjectGram-negative organismeng
dc.subjectCross-border healthcareeng
dc.subjectInfection prevention guidelineseng
dc.subject.ddc610 Medizin
dc.titleCross-border comparison of the Dutch and German guidelines on multidrug-resistant Gram-negative microorganisms
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10038946
dc.identifier.doi10.1186/s13756-015-0047-6
dc.identifier.doihttp://dx.doi.org/10.25646/1951
local.edoc.container-titleAntimicrobial Resistance and Infection Control
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.aricjournal.com/content/4/1/7
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume4
local.edoc.container-issue7
local.edoc.container-year2015

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