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2015-03-17Zeitschriftenartikel DOI: 10.1186/s12889-015-1598-4
From pills to patients: an evaluation of data sources to determine the number of people living with HIV who are receiving antiretroviral therapy in Germany
dc.contributor.authorSchmidt, Daniel
dc.contributor.authorKollan, Christian
dc.contributor.authorStoll, Matthias
dc.contributor.authorStellbrink, Hans-Jürgen
dc.contributor.authorPlettenberg, Andreas
dc.contributor.authorFätkenheuer, Gerd
dc.contributor.authorBergmann, Frank
dc.contributor.authorBogner, Johannes R.
dc.contributor.authorLunzen, Jan van
dc.contributor.authorRockstroh, Jürgen
dc.contributor.authorEsser, Stefan
dc.contributor.authorJensen, Björn-Erik Ole
dc.contributor.authorHorst, Heinz-August
dc.contributor.authorFritzsche, Carlos
dc.contributor.authorKühne, Andrea
dc.contributor.authorHeiden, Matthias an der
dc.contributor.authorHamouda, Osamah
dc.contributor.authorBartmeyer, Barbara
dc.date.accessioned2018-05-07T18:08:46Z
dc.date.available2018-05-07T18:08:46Z
dc.date.created2015-03-25
dc.date.issued2015-03-17none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/revifXh47oZM/PDF/21C11Fj9tTPM.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2030
dc.description.abstractBackground: This study aimed to determine the number of people living with HIV receiving antiretroviral therapy (ART) between 2006 and 2013 in Germany by using the available numbers of antiretroviral drug prescriptions and treatment data from the ClinSurv HIV cohort (CSH). Methods: The CSH is a multi-centre, open, long-term observational cohort study with an average number of 10.400 patients in the study period 2006–2013. ART has been documented on average for 86% of those CSH patients and medication history is well documented in the CSH. The antiretroviral prescription data (APD) are reported by billing centres for pharmacies covering >99% of nationwide pharmacy sales of all individuals with statutory health insurance (SHI) in Germany (~85%). Exactly one thiacytidine-containing medication (TCM) with either emtricitabine or lamivudine is present in all antiretroviral fixed-dose combinations (FDCs). Thus, each daily dose of TCM documented in the APD is presumed to be representative of one person per day receiving ART. The proportion of non-TCM regimen days in the CSH was used to determine the corresponding number of individuals in the APD. Results: The proportion of CSH patients receiving TCMs increased continuously over time (from 85% to 93%; 2006–2013). In contrast, treatment interruptions declined remarkably (from 11% to 2%; 2006–2013). The total number of HIV-infected people with ART experience in Germany increased from 31,500 (95% CI 31,000-32,000) individuals to 54,000 (95% CI 53,000-55,500) over the observation period (including 16.3% without SHI and persons who had interrupted ART). An average increase of approximately 2,900 persons receiving ART was observed annually in Germany. Conclusions: A substantial increase in the number of people receiving ART was observed from 2006 to 2013 in Germany. Currently, the majority (93%) of antiretroviral regimens in the CSH included TCMs with ongoing use of FDCs. Based on these results, the future number of people receiving ART could be estimated by exclusively using TCM prescriptions, assuming that treatment guidelines will not change with respect to TCM use in ART regimens.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectHIV treatmenteng
dc.subjectComposition of ART regimeneng
dc.subjectAntiretroviral drug classeseng
dc.subjectHealth market researcheng
dc.subject.ddc610 Medizin
dc.titleFrom pills to patients: an evaluation of data sources to determine the number of people living with HIV who are receiving antiretroviral therapy in Germany
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10039034
dc.identifier.doi10.1186/s12889-015-1598-4
dc.identifier.doihttp://dx.doi.org/10.25646/1955
local.edoc.container-titleBMC Public Health
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.biomedcentral.com/1471-2458/15/252
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume15
local.edoc.container-issue252
local.edoc.container-year2015

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