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2015-04-12Zeitschriftenartikel DOI: 10.1186/s12889-015-1693-6
Public health management of invasive meningococcal disease in Baden-Wuerttemberg, Germany, 2012: adherence to guidance and estimation of resources required as determined in a survey of local health authorities
dc.contributor.authorMurajda, Lukas
dc.contributor.authorAichinger, Elisabeth
dc.contributor.authorPfaff, Guenter
dc.contributor.authorHellenbrand, Wiebke
dc.date.accessioned2018-05-07T18:12:28Z
dc.date.available2018-05-07T18:12:28Z
dc.date.created2015-04-20
dc.date.issued2015-04-12none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reEzaE8kKZyxI/PDF/225ld7lPtH5do.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2050
dc.description.abstractBackground: Invasive meningococcal disease (IMD) incidence in Germany is low, but management of contacts to prevent subsequent cases still requires resources. Local public health authorities (LHA) advise antibiotic post-exposure prophylaxis (PEP) and vaccination to close contacts as defined in national guidance. We aimed to audit implementation of recommendations for IMD public health management in the state of Baden-Wuerttemberg, Germany, and to estimate associated costs. Methods: We surveyed all 38 LHAs in Baden-Wuerttemberg to evaluate knowledge of national guidance and implementation of IMD contact management using standardized questionnaires. For IMD cases notified in 2012, we requested numbers of household and other contacts ascertained, including advice given regarding PEP and post-exposure vaccination, plus staff time required for their management. We estimated costs for advised antibiotics, LHA staff time and visits to emergency departments according to published sources. The cost of preventing a subsequent case was estimated based on the number of household contacts that received PEP per IMD case and on the previous finding that ~284 household contacts must receive PEP to prevent one subsequent IMD case. Results: Although LHAs were familiar with national recommendations, they did not advise PEP to 4% of household contacts, while 72% and 100% of school and health provider contacts, respectively, were advised PEP. Only 25% of household contacts of a case with a vaccine-preventable serogroup were advised post-exposure vaccination. A mean of 11.0 contacts/IMD case (range 0–51), of which 3.6 were household contacts, were recommended PEP. Per IMD case, mean costs for LHA staff were estimated at €440.86, for antibiotics at €219.14 and for emergency department visits to obtain PEP at €161.70 - a total of €821.17/IMD case. Preventing a subsequent IMD case would cost ~ €65,000. Conclusions: Our results provide insight into costs of IMD public health management in Germany. We identified marked underuse of post-exposure vaccination in household contacts and overuse of PEP in school and health care contacts. In view of an estimated 3–6 quality-adjusted life years lost per case of IMD, our estimated cost of €65,000 for preventing a subsequent case seems justifiable.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectGermanyeng
dc.subjectSporadic invasive meningococcal diseaseeng
dc.subjectPublic health managementeng
dc.subject.ddc610 Medizin
dc.titlePublic health management of invasive meningococcal disease in Baden-Wuerttemberg, Germany, 2012: adherence to guidance and estimation of resources required as determined in a survey of local health authorities
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10039316
dc.identifier.doi10.1186/s12889-015-1693-6
dc.identifier.doihttp://dx.doi.org/10.25646/1975
local.edoc.container-titleBMC Public Health
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.biomedcentral.com/1471-2458/15/371
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume15
local.edoc.container-issue371
local.edoc.container-year2015

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