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2015-06-08Zeitschriftenartikel DOI: 10.1371/journal.pntd.0003891
Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial
dc.contributor.authorBrückner, Sina
dc.contributor.authorAgnandji, Selidji T.
dc.contributor.authorBerberich, Stefan
dc.contributor.authorBache, Emmanuel
dc.contributor.authorFernandes, José F.
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorLoembe, Marguerite Massinga
dc.contributor.authorEngleitner, Thomas
dc.contributor.authorLell, Bertrand
dc.contributor.authorMordmüller, Benjamin
dc.contributor.authorAdegnika, Ayola A.
dc.contributor.authorYazdanbakhsh, Maria
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorEsen, Meral
dc.date.accessioned2018-05-07T18:18:26Z
dc.date.available2018-05-07T18:18:26Z
dc.date.created2015-06-30
dc.date.issued2015-06-08none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/remBNxwnJIjmI/PDF/280o8ykzA4jt.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2082
dc.description.abstractBackground: Helminth infections are a major public health problem, especially in the tropics. Infected individuals have an altered immune response with evidence that antibody response to vaccination is impaired. Hence, treatment of helminth infections before vaccination may be a simple intervention to improve vaccine immunogenicity. In the present study we investigated whether a single-dose antihelminthic treatment influences antibody responses to a seasonal influenza vaccine in primary school children living in Gabon, Central Africa. Methods: In this placebo-controlled double-blind trial conducted in Gabon the effect of a single-dose antihelminthic treatment with 400 mg albendazole versus a placebo one month prior to immunization with a seasonal influenza vaccine was investigated. Antiviral antibody titers against all three vaccine strains were assessed by haemagglutination inhibition (HI) test at baseline (Day 0; vaccination) and four weeks (Day 28) as well as 12 weeks (Day 84) following vaccination. Vaccine-specific memory B-cell response was measured at Day 0 and Day 84 by vaccine-specific Enzyme-linked Immunospot (ELISpot) assay. The trial is registered with the Pan African Clinical Trials Registry (PACTR) (PACTR201303000434188). Results: 98 school children aged 6–10 years were randomly allocated to receive either antihelminthic treatment or placebo and were vaccinated one month after the treatment. The prevalence of helminths at baseline was 21%. Vaccine-specific HI titers against at least one of the three vaccine strains increased at Day 28 and Day 84 in all participants. HI titers against both influenza A strains as well as memory B-cell response were modestly higher in the antihelminthic treated group compared to the placebo group but the difference was not statistically significant. Total but not specific IgA was elevated in the antihelminthic treated group compared to the control group at Day 28. Conclusion: In our setting antihelminthic treatment had no significant effect on influenza vaccine immunogenicity. A trend towards better antiviral and vaccine immunogenicity in the antihelminthic treated group encourages studies to be conducted with alternative treatment schedules or in populations with a higher helminth burden.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectVaccinationeng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectPrevalenceeng
dc.subjectSeasonseng
dc.subjectInfluenza Human/prevention & controleng
dc.subjectInfluenza Human/immunologyeng
dc.subjectChildeng
dc.subjectAntibodies Viral/bloodeng
dc.subjectAntibodies Viral/immunologyeng
dc.subjectInfluenza A Virus H1N1 Subtype/immunologyeng
dc.subjectInfluenza Vaccines/immunologyeng
dc.subjectAlbendazole/therapeutic useeng
dc.subjectAnthelmintics/therapeutic useeng
dc.subjectB-Lymphocytes/immunologyeng
dc.subjectDouble-Blind Methodeng
dc.subjectGabon/epidemiologyeng
dc.subjectHelminthiasis/drug therapyeng
dc.subjectHelminthiasis/epidemiologyeng
dc.subjectHelminthiasis/immunologyeng
dc.subjectHemagglutination Inhibition Testseng
dc.subjectImmunoglobulin Isotypes/bloodeng
dc.subjectImmunoglobulin Isotypes/classificationeng
dc.subjectIntestinal Diseases Parasitic/drug therapyeng
dc.subjectIntestinal Diseases Parasitic/epidemiologyeng
dc.subjectIntestinal Diseases Parasitic/immunologyeng
dc.subject.ddc610 Medizin
dc.titleEffect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10039827
dc.identifier.doi10.1371/journal.pntd.0003891
dc.identifier.doihttp://dx.doi.org/10.25646/2007
local.edoc.container-titlePLoS Neglected Tropical Diseases
local.edoc.container-textBrückner S, Agnandji ST, Berberich S, Bache E, Fernandes JF, Schweiger B, et al. (2015) Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial. PLoS Negl Trop Dis 9(6): e0003768.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003768
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume9
local.edoc.container-issue6
local.edoc.container-year2015

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